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Evaluating the Feasibility and Reliability of Using Handheld Nebulizers to Conduct Cough Sensitivity Testing With Citric Acid

University of Montana · with National Institute of General Medical Sciences (NIGMS) · NCT07531901

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–89 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
10
US sites recruiting
1
Study start
July 15, 2026
Record last updated
July 20, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Objective cough reflex sensitivity testing is typically restricted to specialized research laboratories due to reliance on expensive dosimeter-controlled aerosol delivery systems. This study evaluates the feasibility and reliability of a low-cost alternative method using a handheld nebulizer for citric acid cough challenge testing. Healthy adult participants will complete cough reflex sensitivity testing using both a standard dosimeter-controlled nebulizer system (Cosmed QuarkSpiro) and a handheld nebulizer (DeVilbiss 45). The study will compare cough threshold outcomes between methods to determine whether handheld nebulizer-based testing produces comparable and reproducible measurements.

Being studied: Cosmed QuarkSpiro Dosimeter-Controlled Nebulizer; DeVilbiss 45 Handheld Nebulizer

Conditions: Cough Reflex Sensitivity

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Healthy adults at least 18 years of age
  • Consent to audio/video recording of the research sessions for research purposes
  • Spirometry testing results obtained by study team on same day of first testing session with FEV1/FVC ratio and FEV1 percent predicted values of at least 0.70

Exclusion Criteria

  • Pregnant or trying to become pregnant (if capable of becoming pregnant- a urine pregnancy test will be provided onsite and a negative result must be obtained prior to the first testing session)
  • Smoking of any substance in the last six months
  • Diagnosed or suspected pulmonary disease (e.g., asthma, COPD)
  • History of chronic cough
  • History of head or neck cancer
  • History of neurological disease (e.g., cerebrovascular accident)
  • History of dysphagia (swallowing difficulty)
  • Current complaint of a voice problem
  • Current upper respiratory infection

Recruiting US locations

  • University of Montana

    Missoula, MT 59812

    Site contact: Jane E Salois, PhD · 406-243-2138 · jane.salois@umontana.edu

Study contacts (from the official record)

  • Jane E Salois, PhD · 406-243-2138 · jane.salois@umontana.edu
  • Laurie J Slovarp, PhD · 406-243-2107 · laurie.slovarp@umontana.edu
All healthy volunteers studies in Montana →
Evaluating the Feasibility and Reliability of Using Handheld… (NCT07531901) | Bored Studies