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Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea

Wright State University · NCT06312813

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 2
Target enrollment
48
US sites recruiting
1
Study start
February 27, 2024
Record last updated
February 18, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Rosacea is a common skin condition associated with easy blushing and red face; many patients with rosacea react to sunlight with increased redness. The purpose of this study is to determine if the use of a topical medication will help reduce sunlight induced redness and irritation in patients with rosacea.

Being studied: Imipramine; Amitriptyline; Vehicle

Conditions: Rosacea

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Fitzpatrick Skin Type I - IIII
  • Self-identified rosacea or no history of flushing/blushing for controls
  • Able to provide medical history and list of medications -- control subjects will not be allowed to take medications that are known to be photosensitizers.

Exclusion Criteria

  • Using imipramine, amitriptyline or any other tricyclic antidepressant (oral or topical)
  • Using topical anti-inflammatory (within 1 week) or systemic agents (e.g. prednisone)
  • Large tattoos in the designated testing areas
  • Tanning bed use within last 3 months
  • Photodynamic Therapy or UCB treatments in past 3 months
  • Female Subjects: pregnant or nursing

Recruiting US locations

  • Wright State Physicians

    Fairborn, OH 45324

    Site contact: Pharmacology Translational Unit · (937)-245-7500 · pturesearch@wrightstatephysicians.org

Study contacts (from the official record)

  • Manager Clinical Research Operations · (937)-245-7500 · pturesearch@wrightstatephysicians.org
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Evaluating Use of Topical Imipramine and Amitriptyline in Reducing… (NCT06312813) | Bored Studies