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RecruitingAccepts healthy volunteersEarly Phase 1

Evaluation of [18F]GATT-44 for Positron Emission Tomography Imaging of the GABA Transporter-1

Yale University · with National Institute of Mental Health (NIMH) · NCT07457736

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–60 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
32
US sites recruiting
1
Study start
January 28, 2026
Record last updated
August 20, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Evaluate [18F]GATT-44 (aka [18F]GAT44), to characterize its pharmacokinetic, metabolic, and in vivo binding profile, and assess the reproducibility of kinetic and binding parameters. Assess specific binding levels of [18F]GATT-44 by conducting a test-block study in humans. Estimate human dosimetry of [18F]GATT-44 by performing whole-body imaging studies.

Being studied: [ 18F]GATT-44

Conditions: Healthy Adult Participants

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Willing and able to give voluntary written informed consent;
  • Able to read and write, able to communicate effectively with the investigator, and comply with all study requirements, restrictions, and directions of the research staff;
  • Male or female, aged 18 to 60, at screening;
  • In good general health as evidenced by medical history, physical examination, ECG, serum/urine biochemistry, hematology, and serology tests;
  • Females of childbearing potential, and male subjects, must be willing to practice birth control for the duration of the study (unless medical documentation is provided confirming subject is permanently sterile).

Exclusion

  • Less than 18 years of age;
  • Pregnant or breastfeeding;
  • Any significant systemic illness or unstable medical condition;
  • Pre-existing medical conditions or claustrophobic reactions;
  • Research-related radiation exposure exceeds current PET Center guidelines;
  • History of a bleeding disorder or are currently taking anticoagulants.

Recruiting US locations

  • Yale University PET Center

    New Haven, CT 06519

    Site contact: Shannan Henry · +1 (203) 737-5278 · shannan.henry@yale.edu

Study contacts (from the official record)

  • Shannan Henry · +1 (203) 737-5278 · shannan.henry@yale.edu
  • Kayla R Cottiers · 203-737-7496 · kayla.cottiers@yale.edu
All healthy volunteers studies in Connecticut →
Evaluation of [18F]GATT-44 for Positron Emission Tomography… (NCT07457736) | Bored Studies