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Exercise and Protein Efficiency in T2D

University of Illinois at Urbana-Champaign · with American Diabetes Association · NCT07477067

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 65+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
30
US sites recruiting
1
Study start
February 9, 2026
Record last updated
April 29, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

In this randomized controlled trial, 30 older adults (aged> 65 years; 15 with T2D, 15 controls) will participate in a 12-week progressive exercise training program. They will undergo pre- and post-testing that includes body composition measures; oral glucose tolerance testing; cardiovascular fitness and muscle performance testing; dietary protein efficiency assessed using the indicator amino acid oxidation (IAAO) method; and a gut microbiota trial. The dietary protein efficiency trial will include repeated ingestion of crystallized amino acids (drink) containing stable isotopes, urine samples, and breath samples. The gut microbiome trial will consist of a single ingestion of a Mediterranean-based modeled meal enriched with 13C-phenylalanine (in the drink) and repeated blood draws. Participants will also be asked to give a fecal sample after the gut microbiome trial.

Being studied: 12 week progressive exercise training

Conditions: Type 2 Diabetes; Control Condition

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • At least 65 years old
  • Body mass index: 25-40 kg/m\^2
  • Female: Waist to hip ratio >0.8
  • Male: Waist to hip ratio >1.0
  • Free from structured exercise during the prior 6 months (mo) weight stable for the prior 6 months

T2D group:

-Diagnosed by a physician with elevated glycosylated hemoglobin (HbA1c) >6.5%

Control group

-Normoglycemic with HbA1c levels not exceeding 5.6% and fasting blood glucose levels below or equal to 99 mg/dL (5.5mmol)

Exclusion Criteria

  • Uncontrolled diabetes (evidence of HbA1c > 10%, prescription of insulin)
  • Diagnoses of diabetic neuropathy or failing diabetic neuropathy screening
  • Statins
  • Peripheral edema Consumption of ergogenic-levels of dietary supplements that may affect muscle mass (e.g., creatine, HMB), insulin-like substances, or anabolic/catabolic pro-hormones (e.g., DHEA) within 6 weeks prior to participation.
  • Untreated hypothyroidism, epilepsy, medications that affect vasoactivity, possibility of pregnancy, and any neurological, cardiovascular, or musculoskeletal disease that precludes exercise testing.

Recruiting US locations

  • Freer Hall - University of Illinois

    Urbana, IL 61801

    Site contact: Nicholas Burd (Professor), PhD · 2172440970 · naburd@illinois.edu

Study contacts (from the official record)

  • Nicholas Burd (Professor), PhD · 2172440970 · naburd@illinois.edu
  • Gena Irwin (Research Assistant), M.S · 3608883281 · genai2@illinois.edu
All weight loss studies in Illinois →
Exercise and Protein Efficiency in T2D (NCT07477067) | Bored Studies