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Exploring the Role of Neuroactive Steroids in Tourette Syndrome

University of Utah · with University of Miami, Albert Einstein College of Medicine · NCT05281445

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 8–12 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
120
US sites recruiting
1
Study start
May 15, 2023
Record last updated
October 6, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Tourette syndrome (TS) is a disabling neurodevelopmental disorder characterized by motor and phonic tics. The studies proposed in this application will explore the endocrine mechanisms underlying two of the least well-understood biological characteristics of TS, namely its marked male predominance and stress susceptibility. In particular, our exploratory studies will characterize the steroid profile in TS-affected boys and girls to identify novel potential biomarkers and therapeutic targets for this disorder.

Being studied: Tic suppression task

Conditions: Tourette Syndrome in Children

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Diagnostic criteria of TS for cases (and lack of any tic disorders for controls)
  • Age between 8 and 12 years old (this age range is to ensure that TS participants can perform the tic suppression task)
  • confirmation of sexual development by parent and/or self-reported Tanner stage of pubic hair development.

Exclusion Criteria

  • major psychiatric disorders such as a psychotic disorder, autism spectrum disorder, conduct disorder, and substance use disorder;
  • other neurological disorders;
  • clinically significant endocrinological disorders;
  • use of therapies that can modify hormonal profile;
  • pharmacotherapies that may change stress sensitivity, such as antidepressants and anxiolytics.

Recruiting US locations

  • University of Utah

    Salt Lake City, UT 84112

    Site contact: Michael Himle, PhD · 8015817529 · michael.himle@utah.edu

Study contacts (from the official record)

  • Marco Bortolato, MD PhD · 8015873352 · marco.bortolato@utah.edu
  • Michael Himle, PhD · 8015817529 · michael.himle@utah.edu
All healthy volunteers studies in Utah →
Exploring the Role of Neuroactive Steroids in Tourette Syndrome (NCT05281445) | Bored Studies