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RecruitingAccepts healthy volunteersPhase 1

Exploring the Utility of [18F]3F4AP for Demyelination Imaging

Yale University · with National Institute for Biomedical Imaging and Bioengineering (NIBIB), National Institute on Aging (NIA) · NCT06999434

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–90 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 1
Target enrollment
105
US sites recruiting
1
Study start
May 5, 2025
Record last updated
September 9, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The overall objective is to obtain an assessment of the pharmacokinetics of [18F]3F4AP in healthy volunteers and subjects with demyelinating diseases such as mild cognitive impairment (MCI), Alzheimer's Disease (AD), Multiple Sclerosis (MS), Spinal Cord Injury (SCI) and Spinal radiculopathy (SR).

Being studied: [ 18F]3F4AP; [18F]MK6240; [11C]PIB

Conditions: Demyelinating Disorders; MCI; Alzheimer's Disease (AD); MS (Multiple Sclerosis); SCI - Spinal Cord Injury; Spinal Radiculopathy

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion

  • Male and Female subjects must be ≥18 and \<90 years of age;
  • Able to understand and provide informed consent prior to study procedures
  • Must be in good health

Exclusion

  • Less than 18 years of age;
  • Pregnant or breastfeeding;
  • Any significant systemic illness or unstable medical condition;
  • Pre-existing medical conditions or claustrophobic reactions;
  • Research-related radiation exposure exceeds current PET Center guidelines (i.e. 50 mSv in the prior 12 months);
  • History of a bleeding disorder or are currently taking anticoagulants.

Recruiting US locations

Study contacts (from the official record)

  • Shannan Henry · +1 (203) 737-5278 · shannan.henry@yale.edu
  • Kayla Cottiers · 203-737-7496 · kayla.cottiers@yale.edu
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Exploring the Utility of [18F]3F4AP for Demyelination Imaging (NCT06999434) | Bored Studies