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Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study

University of Delaware · with National Heart, Lung, and Blood Institute (NHLBI) · NCT06094816

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 40–60 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
120
US sites recruiting
1
Study start
March 5, 2024
Record last updated
March 24, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The overall objective of this project is to identify the key salt-sensing regions of the brain and determine the underlying mechanism of sodium sensing. The investigators will assess how the brain responds to an acute increase of salt in the blood using MRI. This will be done during a 30-minute infusion of a saline solution containing 3% salt. One trial will be conducted with a salt sensing channel blocker and one trial without the salt sensing channel blocker. This will help to assess the role of a specific salt sensing channel in the brain. Salt sensitivity of BP will be assessed using 7-day dietary feeding where participants will be given food to consume for 7-days. Comparisons will be made between salt resistant (no change in blood pressure going from low to high salt diets) and salt sensitive adults (a change in blood pressure going from low to high salt diets). The investigators think the changes in MRI will be greater in salt sensitive compared to salt resistant subjects.

Being studied: Furosemide (Diuretic); Hypertonic Saline Infusion

Conditions: Salt-Sensitivity of Blood Pressure

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age: > 40 years or \< 60 years
  • Blood pressure: > 100/60 mmHg or \< 140/90 mmHg
  • BMI: > 18.5 kg/m2 or \< 35 kg/m2
  • Serum potassium: > 3.5 mmol/L or \< 5.5 mmol/L
  • No history of cardiovascular, renal, metabolic, or neurological disease

Exclusion Criteria

  • Age: \< 40 years or > 60 years
  • Blood pressure: \< 100/60 mmHg or > 140/90 mmHg
  • BMI: \< 18.5 kg/m2 or > 30 kg/m2
  • Serum potassium: \< 3.5 mmol/L or > 5.5 mmol/L
  • Abnormal ECG
  • History of - cardiovascular, cancer, metabolic, respiratory, renal disease
  • Hormone replacement therapy
  • Current tobacco or nicotine use
  • Pregnant or nursing mothers
  • Major brain injury (concussions do not count)
  • Clinically diagnosed psychiatric or neurological disorder
  • Clinically diagnosed anxiety or depression
  • Psychiatric, neurological, anxiety or depression medications
  • Hypertension medications
  • Sulfonamide drug allergy
  • Contra-indications to MRI (implants, metal, etc)
  • Claustrophobia

Recruiting US locations

  • University of Delaware

    Newark, DE 19713

    Site contact: Ginny Nuckols, PhD · gnuckols@udel.edu

Study contacts (from the official record)

  • Megan Wenner, PhD · 3028317343 · mwenner@udel.edu
  • Virginia Nuckols, PhD · gnuckols@udel.edu
All heart & blood pressure studies in Delaware →
Forebrain Electroneutral Transporters in Salt-sensitive… (NCT06094816) | Bored Studies