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GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study

University of Alabama at Birmingham · with National Heart, Lung, and Blood Institute (NHLBI) · NCT05216042

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
200
US sites recruiting
1
Study start
April 1, 2022
Record last updated
October 5, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes and poor cardiometabolic health. Obese and Black individuals have \~30% lower levels of NP and are at a greater risk of developing cardiovascular (CV) events as compared to lean and White counterparts. Some people have common genetic variations that cause them to have \~20% lower NP levels. Similar to other low NP populations, these individuals with low NP genotype (i.e., carrying a common genetic variation called rs5068) are at a greater risk of developing cardiometabolic diseases. By understanding the NP response following the exercise challenge and the glucose challenge in individuals with genetically lower NP levels will help us understand how to improve cardiometabolic health in them.

Being studied: Study diet; Exercise capacity VO2 max determination; Exercise Challenge; Glucose Challenge

Conditions: Cardiovascular Diseases; Natriuretic Peptides; Cardiometabolic Diseases; Energy Expenditure; Glucose Metabolism; Exercise; Obesity

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Adults: Age more than or equal to 18; an equal number of Males and Females
  • Consent to the collection of genetic material
  • Willing to adhere to the study protocol

Exclusion Criteria

  • Age \<18, at screening.
  • BMI >45 kg/m2.
  • Blood pressure more than 140/90 mmHg.
  • Participants who are taking more than 2 hypertension medications.
  • History of diabetes or fasting plasma glucose >126 mg/dl or HbA1C>=6.5% or prior treatment with antidiabetic medication.
  • Have any past or present history of cardiovascular diseases (stroke, seizure, myocardial infarction, heart failure, transient ischemic attack, angina, or cardiac arrhythmia)
  • Women who are pregnant or breastfeeding or who can become pregnant and not practicing an acceptable method of birth control during the study (including abstinence);
  • Estimated GFR \< 60 ml/min/1.73 m2; albumin creatinine ratio ≥30 mg/g
  • Hepatic Transaminase (AST and ALT) levels >3x the upper limit of normal
  • Anemia (men, Hct \< 38%; women, Hct \<36%)
  • Inability to exercise on a treadmill

Recruiting US locations

  • University of Alabama at Birmingham

    Birmingham, AL 35294

    Site contact: Nehal Vekariya, MS · 205-934-7173 · nvekariya@uabmc.edu

Study contacts (from the official record)

  • Nehal Vekariya, MS · 205-934-7173 · nvekariya@uabmc.edu
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GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic… (NCT05216042) | Bored Studies