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Genomic Predictors of Recurrent Pregnancy Loss

Yale University · with Johns Hopkins University, University of Texas at Austin · NCT05444283

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–50 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
500
US sites recruiting
9
Study start
September 1, 2021
Record last updated
May 22, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The overall goals of this proposal are to determine the genetic architecture of recurrent pregnancy loss (RPL) and to discover genomic predictors of RPL.

Conditions: Recurrent Pregnancy Loss

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Cohort A - Fetal Intolerome Cohort

Inclusion Criteria

  • Women with loss of a current singleton pregnancy at \< 20 0/7 weeks gestation, documented by ultrasonography or histopathological examination
  • History of one or more prior pregnancy losses
  • Euploid current pregnancy confirmed by karyotype, microarray, or STORK (Short-read Transpore Rapid Karyotyping) sequencing Note: A limited number of aneuploid losses will be included as part of the pilot phase

Exclusion Criteria

  • History of parental karyotype abnormalities
  • History of antiphospholipid antibody syndrome
  • Evidence of uncontrolled diabetes
  • Evidence of uncontrolled thyroid disease
  • History of autoimmune disease related to pregnancy loss (e.g., systemic lupus erythematosus, rheumatoid arthritis)
  • History of uterine anomalies
  • History of cervical insufficiency

Cohort B - Maternal Effect Gene Cohort

Inclusion Criteria

  • Women with a history of three or more pregnancy losses of unknown cause, with or without a liveborn child

Exclusion Criteria

  • Known etiology for pregnancy loss

Recruiting US locations

  • University of Colorado

    Aurora, CO 80045

    Site contact: Asma Giornazi, MS · 720-276-8941 · asma.giornazi@ucdenver.edu

  • Yale University

    New Haven, CT 06511

    Site contact: Yong-Hui Jiang, MD, PhD · 203-785-2429 · yong-hui.jiang@yale.edu

  • Northwestern University

    Chicago, IL 60611

    Site contact: Riley Bonaccorsi · 312-694-6678 · riley.bonaccorsi@nm.org

  • Johns Hopkins University

    Baltimore, MD 21205

    Site contact: Samya El Sayed, MD · 443-473-2674 · selsaye4@jh.edu

  • Wayne State University

    Detroit, MI 48201

    Site contact: Michelle Yoscovits · 313-577-8016 · mbrossoi@med.wayne.edu

  • Columbia University

    New York, NY 10032

    Site contact: Jessica Giordano, CGC · 516-521-5604 · jlg2197@cumc.columbia.edu

  • Pennsylvania State University

    Hershey, PA 17033

    Site contact: Robinn Moyer · 717-531-6272 · Rmoyer3@pennstatehealth.psu.ed

  • University of Texas at Austin

    Austin, TX 78712

    Site contact: Elizabeth Davis, RN · 512-495-2103 · elizabethrose.davis@austin.utexas.edu

  • University of Texas at San Antonio

    San Antonio, TX 78299

    Site contact: Susie Reyes, RN · 210-450-5384 · reyessr@uthscsa.edu

Study contacts (from the official record)

  • Yong-Hui Jiang, MD, PhD · 2037852429 · yong-hui.jiang@yale.edu
  • Heping Zhang, PhD · 12037855185 · heping.zhang@yale.edu
All pregnancy studies in Colorado →
Genomic Predictors of Recurrent Pregnancy Loss (NCT05444283) | Bored Studies