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RecruitingAccepts healthy volunteersEarly Phase 1

Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass

The University of Texas Health Science Center at San Antonio · NCT01803451

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–65 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
80
US sites recruiting
2
Study start
November 2005
Record last updated
September 9, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The overall goal of this project is to understand the mechanisms by which gastric bypass surgery improves glucose metabolism.

The central hypothesis guiding this project is that the reconfiguration of intestinal transit with the Roux-en-Y will increase the release of insulinotropic GI hormones, termed incretins that improve insulin secretion and glucose metabolism. The study is divided into three specific aims.

  • To determine the role of incretin hormones on insulin secretion in patients with gastric bypass surgery using intravenous-oral hyperglycemic clamp.
  • To compare incretin effect and glucose tolerance among patient who suffer from hypoglycemia after RYGB and asymptomatic surgical and non-surgical individuals.
  • To quantify the contribution of GLP-1 to incretin effect enhancement following surgery.

Being studied: exendin-(9-39); exendin -(9-39)

Conditions: Post-bariatric Surgery

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • age 18-65
  • healthy control without diabetes or active organ disease
  • Individuals with bariatric surgery
  • recurrent hypoglycemia post gastric bypass

Exclusion Criteria

  • pregnancy
  • significant anemia
  • diabetes currently unless pre-op for bariatric surgery procedure
  • GI obstruction

Recruiting US locations

  • Texas Diabetes Institute - University Health System

    San Antonio, TX 78207

    Site contact: Jennifer Foster, MSN · 210-450-8696 · fosterj6@uthscsa.edu

  • South Texas Veterans Health Care System

    San Antonio, TX 78229

    Site contact: Marzieh Salehi, MD MS · 210-567-6691 · salehi@uthscsa.edu

Study contacts (from the official record)

  • Marzieh Salehi, MD MS · 210-567-6691 · salehi@uthscsa.edu
  • Jennifer Foster, MSN · 210-450-8696 · fosterj6@uthscsa.edu
All healthy volunteers studies in Texas →
Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass (NCT01803451) | Bored Studies