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Glycemic/Insulinemic Effects of Fresh Mango as a Sugar Substitute in Realistic Breakfasts.

Ball State University · with National Mango Board · NCT07045051

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–45 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
24
US sites recruiting
1
Study start
March 26, 2025
Record last updated
July 1, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Large blood sugar and insulin increases after meals high in table sugar are related to risk for diabetes and heart disease. Additionally, large increases in blood sugar may also negatively impact vascular health. Previous research suggests that mango consumed in small quantities has blood sugar-lowering properties, but the evidence of this within larger, more realistic meals is limited. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which also contains fiber and plant bioactives) will lead to more favorable blood sugar, insulin, and vascular responses after eating breakfast meals. The investigators will compare the postprandial glycemic, insulinemic, and vascular response to low and high glycemic meals sweetened with either fresh mango or sucrose.

Being studied: Low-Glycemic Breakfast Containing Oats and Mango; High-Glycemic Breakfast Containing Cereal and Mango; Low-Glycemic Breakfast Containing Oats and Table Sugar; High-Glycemic Breakfast Containing Cereal and Table Sugar

Conditions: Healthy Participants

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 18 - 45 years.
  • Body mass index between 18.5-35.0 kg/m2
  • Not pregnant (females only)
  • Not postmenopausal (females only).
  • Not been diagnosed with cardiovascular disease.
  • Not been diagnosed with a cardiometabolic conditions (e.g., type 2 diabetes)
  • Not been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
  • Does not regularly take anti-inflammatory drugs (more than 2x week).
  • Does not use glucose-lowering drugs (e.g., metformin)
  • Does not use lipid-lowering drugs (e.g., statins)
  • Does not use tobacco products or any illicit drugs.
  • Does not have a pacemaker.
  • Can consume mango, wheat, gluten, and milk.
  • Can stay in a supine position in the dark for at least ten minutes.

Exclusion Criteria

  • Not between the ages of 18-45
  • Body mass index \< 18.5 kg/m2 or >35.0 kg/m2
  • Pregnant (females only)
  • Postmenopausal status (females only).
  • Been diagnosed with cardiovascular disease.
  • Been diagnosed with a cardiometabolic conditions (e.g., type 2 diabetes)
  • Been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
  • Regularly take anti-inflammatory drugs (more than 2x week).
  • Uses glucose-lowering drugs (e.g., metformin)
  • Uses lipid-lowering drugs (e.g., statins)
  • Uses tobacco products or any illicit drugs.
  • Have a pacemaker.
  • Allergic to mango, wheat, gluten, and/or milk.
  • Unable to lay in supine position in the dark for at least ten minutes.

Recruiting US locations

  • Health Professions Building, Ball State University

    Muncie, IN 47306

    Site contact: Bryant Keirns, PhD · 765-285-8356 · bryant.keirns@bsu.edu

Study contacts (from the official record)

  • Bryant Keirns, PhD · 765-285-8356 · bryant.keirns@bsu.edu
All healthy volunteers studies in Indiana →
Glycemic/Insulinemic Effects of Fresh Mango as a Sugar Substitute… (NCT07045051) | Bored Studies