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Greater Houston Area Pediatric Bipolar Registry

The University of Texas Health Science Center, Houston · with John S. Dunn Foundation · NCT06665984

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 6–17 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
1000
US sites recruiting
1
Study start
December 6, 2022
Record last updated
February 18, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to perform a comprehensive research assessment of children and adolescents who meet The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) criteria for Bipolar Disorder (BD) , offspring of a parent with BD, and healthy controls (HC), to obtain blood samples and saliva samples from each subject to allow the evaluation for BD biomarkers and genetic information, to notify participants about future research studies they may qualify for , to recommend follow-up with an outpatient provider if needed and to use magnetic resonance imaging (MRI) (structural MRI and diffusion tensor imaging) to investigate brain structures and relevant pathways associated with mood and behavioral regulation, conversion from softer forms of the BD spectrum (BD-NOS) to harder forms (BD-I and BD-II) and possible early identification.

Conditions: Pediatric Bipolar Disorder

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria for bipolar patients or offspring of bipolar parents:

  • Any current mood state (in the case of bipolar subjects)
  • For bipolar patients: DSM-V criteria for BD type I, BD type II, or BD NOS, as per the administration of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)
  • For the offspring of bipolar parents: at least one parent meeting DSM-V criteria for BD type I or BD type II, or BD NOS as per the administration of the MINI Adult

Exclusion Criteria for bipolar patients or offspring of bipolar parents:

  • Autism Spectrum Disorder (ASD)
  • Developmental Intellectual Disorder
  • Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)
  • Schizophrenia
  • Uncontrolled or severe medical problem per investigator judgment
  • For the offspring: parents with a history of any brain diseases, including seizures, stroke, meningitis, encephalitis, dementia, and other degenerative brain diseases; parents with a history of intellectual disability

Exclusion Criteria for healthy control subjects:

  • Any Psychiatric Diagnosis
  • Any family history of Bipolar Disorder, Psychotic Disorder, Schizophrenia, or Schizoaffective disorder in a first-degree relative
  • Any family history of a neurological condition in a first-degree relative.
  • Mental Retardation/Intellectual Disability
  • Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)
  • Schizophrenia
  • Uncontrolled or severe medical problem per investigator judgement

Exclusion criteria for annual visits

  • Autism Spectrum Disorders (ASD)
  • Intellectual Developmental Disorder
  • Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)
  • Schizophrenia
  • Uncontrolled or severe medical problem per investigator judgement

Recruiting US locations

  • The University of Texas Health Science Center at Houston

    Houston, TX 77479

    Site contact: Jair C Soares, M.D. PhD · (713) 486-6663 · utmooddisorders@uth.tmc.edu

Study contacts (from the official record)

  • Jair C Soares, M.D. PhD · (713) 486-6663 · utmooddisorders@uth.tmc.edu
  • Courtney Vecera · (713) 486-6663 · utmooddisorders@uth.tmc.edu
All mental health studies in Texas →
Greater Houston Area Pediatric Bipolar Registry (NCT06665984) | Bored Studies