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guideSEQ: Genomic Understanding, Impact, Decision & Ethics in Prenatal Sequencing

Columbia University · with Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · NCT07610590

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
1042
US sites recruiting
1
Study start
April 29, 2026
Record last updated
July 15, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study looks at whether genome sequencing should be used more routinely during pregnancy, even when ultrasounds look normal. Genome sequencing can examine nearly all of a baby's genes and may find genetic conditions that standard tests do not detect. Researchers will compare this test with current prenatal testing to see if it provides helpful information for families and doctors. The study will also explore how parents decide what kinds of genetic information they want to receive and how this information affects their experience during pregnancy. The goal is to understand whether genome sequencing can be used in a way that is helpful, responsible, and supportive for families in the future.

Being studied: Genome Sequencing (GS)

Conditions: Prenatal Genetic Diagnosis

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Patient planned chorionic villus sampling (CVS) or amniocentesis in the absence of major fetal structural anomalies (minor anomalies are eligible, the HPO (Human Phenotype Ontology) will not be used by the analyst)
  • Certified genetic counselor involved in care

Exclusion Criteria

  • A major structural anomaly
  • Maternal or paternal age less than 18 years old
  • Parental unwillingness to participate in 1 year of postnatal follow-up
  • Language barrier (non-English or Spanish speaking)

Recruiting US locations

  • Columbia University Irving Medical Center (CUIMC)

    New York, NY 10032

    Site contact: Camila Zarate, MPH · 646-300-0197 · cz2888@cumc.columbia.edu

Study contacts (from the official record)

  • Camila Zarate, MPH · 646-300-0197 · cz2888@cumc.columbia.edu
  • Jessica Giordano, MS, CGC · 516-521-5604 · jlg2197@cumc.columbia.edu
All pregnancy studies in New York →
guideSEQ: Genomic Understanding, Impact, Decision & Ethics in… (NCT07610590) | Bored Studies