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RecruitingAccepts healthy volunteersEarly Phase 1

HA35 Acute Alcohol Study

The Cleveland Clinic · NCT05025865

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 21–65 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
24
US sites recruiting
1
Study start
February 1, 2022
Record last updated
September 24, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Eligible subjects will be asked to take a placebo/treatment capsule for a total of 3 days and then participate in a study visit on the fourth day. This study visit will include a medical exam, clinical labs, questionnaires, body composition measurements, and urine and stool collections. Additionally, participants will consume a sugar cocktail to measure their gut permeability, participate in an acute ethanol challenge, and undergo two muscle biopsies. The study will take approximately 3-4 hours and a designated driver will need to drive the participant home. On the fifth day, you will be asked to return to drop of the 24-hour urine collection.

Being studied: Sodium Hyaluronate; Placebo

Conditions: Healthy Controls

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Alcohol consumption of less than 7 drinks per week for women and less than 14 drinks per week for men
  • Ability to understand and willingness to provide written consent

Exclusion Criteria

  • Any known chronic illness including but not limited to cancer (except non-melanoma skin cancer)
  • Poorly controlled diabetes (Hemoglobin A1c >9.5 g/dl)
  • Untreated hyper/hypothyroidism
  • Uncontrolled hypertension or hypercholesterolemia
  • End-stage renal disease
  • Liver disease of any etiology
  • Coronary artery disease or stroke
  • Active intravenous drug use
  • History of gastric bypass
  • Medications known to alter muscle protein synthesis (systemic corticosteroids, tamoxifen, high dose estrogen, testosterone, or anabolic steroids)
  • Pregnancy
  • Past alcohol use disorder
  • Abnormal clotting factors

Recruiting US locations

  • Cleveland Clinic

    Cleveland, OH 44195

    Site contact: Annette Bellar · bellara@ccf.org

Study contacts (from the official record)

  • Srinivasan Dasarathy, MD · 216-318-7010 · dasaras@ccf.org
  • Annette Bellar · bellara@ccf.org
All healthy volunteers studies in Ohio →
HA35 Acute Alcohol Study (NCT05025865) | Bored Studies