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HELIOS Advanced: Human Oocyte Illumination to Enhance Development

Columbia University · NCT07425080

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–48 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
270
US sites recruiting
1
Study start
March 24, 2026
Record last updated
March 25, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Oocytes need a lot of energy to complete meiosis and fertilize successfully. As women get older, the "power plants" of the cells (called mitochondria) don't work as well. This makes it harder for eggs and embryos to develop normally. One possible way to help is with a gentle light treatment called photobiomodulation (PBM). This uses a special type of red light that boosts energy production in cells and helps them stay healthy. This study will test whether adding this light treatment during in vitro fertilization (IVF) can improve embryo growth and pregnancy outcomes.

Being studied: Photobiomodulation

Conditions: IVF Outcomes

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Female age between 18-48 years at the time of the IVF/ICSI cycle
  • Undergoing blastocyst culture
  • Using own oocytes
  • Has at least two oocytes available for randomization
  • Consenting to oocyte level randomization
  • Plan to transfer euploid embryo within 6 months

Exclusion Criteria

  • Use of donor oocytes or gestational carrier
  • Concurrent experimental laboratory inventions outside of protocol
  • Refusal of randomization or request for non-standard handling

Recruiting US locations

  • Columbia University Fertility Center

    New York, NY 10019

    Site contact: Laura C Gemmell, MD, MSc · 646-756-8282 · lg3094@cumc.columbia.edu

Study contacts (from the official record)

  • Samuel Zev Williams, MD, PhD · 646-756-8282 · zw2421@cumc.columbia.edu
  • Laura C Gemmell, MD, MSc · 646-756-8282 · lg3094@cumc.columbia.edu
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HELIOS Advanced: Human Oocyte Illumination to Enhance Development (NCT07425080) | Bored Studies