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High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans

VA Office of Research and Development · NCT05625204

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 65+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
200
US sites recruiting
1
Study start
January 29, 2024
Record last updated
December 12, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Frailty is defined as a greater susceptibility to stressors resulting from age-related impairments in adaptive biological systems. Frailty leads to poorer physical performance and functional capacity and higher risk of adverse outcomes including falls, hospitalization, and mortality. Resilience, defined as the capacity to recover from disruptions to homeostasis, is critical to successful aging because it precedes frailty and enhances adults' ability to maintain optimal health and function well into older age. Evidence- based therapies to help older adults enhance resilience are limited and the biological underpinnings contributing to improved resilience have not yet been fully characterized. To address this important need, the investigators will conduct a clinical trial to examine the benefits of center- and home-based high intensity interval training (HIIT) on functional capacity, frailty, and resilience, and also to identify novel biomarkers of resilience in older Veterans.

Being studied: Center based attention (stretching only) control; Center based HIIT; Home based HIIT

Conditions: Frailty

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Ages 65 years and older
  • Male and female, any race
  • Medically cleared for exercise
  • Non-frail or pre-frail (frailty score \< 3)
  • Ability to use a recumbent exercise bike

Exclusion Criteria

  • Severe co-morbidity: COPD (GOLD stage IV), CKD ( stage 3)), severe HTN (180 mmHg/120 mmHg)
  • VA-SLUMS score 20 or lower (Cognition)

Recruiting US locations

  • Kansas City VA Medical Center, Kansas City, MO

    Kansas City, MO 64128-2226

    Site contact: Ramratan R Sharma, PhD MHSA · (816) 922-2757 · ram.sharma2@va.gov

Study contacts (from the official record)

  • Kenneth L Seldeen, PhD · (716) 888-4869 · Kenneth.Seldeen@va.gov
  • Bruce R Troen, MD · (816) 922-2755 · Bruce.Troen@va.gov
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High Intensity Interval Training (HIIT) to Reduce Frailty and… (NCT05625204) | Bored Studies