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Hormone-free Antral Retrieval for Viable Embryo Storage & Transfer

Kevin Doody · with Lavima Fertility · NCT07801105

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–35 · Women only
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Not applicable
Target enrollment
30
US sites recruiting
1
Study start
September 2026
Record last updated
September 9, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study is testing whether eggs can be collected from small follicles without using the usual ovarian stimulation medications. Participants will have up to three egg retrieval procedures. The eggs collected during each retrieval will be matured in the laboratory using the CAPA-IVM (Capacitation In Vitro Maturation) process, fertilized, grown into embryos, and tested to identify chromosomally normal embryos.

Embryos from the retrievals may be frozen and accumulated. If a suitable embryo is available, one chromosomally normal embryo may be transferred. The study will also monitor safety, hormone levels, follicle development, embryo development, pregnancy results, and how well participants tolerate the study procedures.

Being studied: CAPA-IVM System; Serial Unstimulated Transvaginal Oocyte Retrieval; ICSI, Blastocyst Culture, PGT-A, Embryo Vitrification/Accumulation, and Single Euploid Embryo Transfer

Conditions: Infertility

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Signed informed consent.
  • Female participant aged 18-35 years.
  • Diagnosis of infertility requiring IVF/ICSI, including unexplained infertility or mild male factor infertility.
  • BMI 18-30 kg/m².
  • AMH ≥2.5 ng/mL.
  • AFC ≥12.
  • Basal FSH \<8 IU/L.
  • Ovaries accessible for transvaginal retrieval.
  • Willing to undergo serial unstimulated TVORs with adaptive retrieval timing.
  • Willing to undergo CAPA-IVM, ICSI, blastocyst culture, PGT-A, embryo vitrification/accumulation, and single euploid embryo transfer.
  • Willing to undergo serial ultrasound and endocrine monitoring.
  • Willing and able to comply with study procedures and follow-up.

Exclusion Criteria

  • Prior ovarian surgery.
  • Ovarian endometrioma.
  • Inaccessible ovaries.
  • Significant uterine factor expected to compromise implantation, pregnancy, or live birth.
  • Significant medical comorbidity that would increase risk of TVOR, pregnancy, or study participation.
  • AMH \<2.5 ng/mL.
  • AFC \<12.
  • Basal FSH ≥8 IU/L.
  • BMI \<18 or >30 kg/m².
  • Current smoking or nicotine use within 3 months of screening.
  • Active pelvic infection, untreated STI, or acute urinary tract infection.
  • Contraindication to transvaginal oocyte retrieval, anesthesia/sedation, pregnancy, or antibiotic prophylaxis.
  • Known chromosomal abnormality in the participant or sperm source that would confound study outcome assessment.
  • Severe male factor infertility requiring surgical sperm retrieval, unless specifically permitted by the final protocol.
  • Recent exposure to teratogenic radiation, drugs, or toxins.
  • Current participation in another interventional clinical trial that may confound outcomes.
  • Previous participation in the CARE study.

Recruiting US locations

  • CARE Fertility Texas

    Bedford, TX 76104

    Site contact: Kevin Doody, MD · 8179241572 · kevind@embryo.net

Study contacts (from the official record)

  • Kevin Doody, MD · 817-924-1572 · kevind@embryo.net
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Hormone-free Antral Retrieval for Viable Embryo Storage & Transfer (NCT07801105) | Bored Studies