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How a Single Workout Affects Gut Bugs in Women With Different Fitness Levels and Body Types

George Washington University · NCT06691100

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 21–40 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
40
US sites recruiting
1
Study start
October 16, 2024
Record last updated
September 9, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study aims to elucidate the differences in the gut microbiome functional activity and metabolome in adult premenopausal women with distinctive fitness levels and BMIs (with obesity, w/o obesity). The specific aims are as follows:

  • Aim 1: To examine the effects of acute aerobic exercise at 60-70% heart rate reserve (HRRmax) for 30 minutes bout on changes in the abundance of SCFA-producing bacteria and their functional downstream metabolic activity.
  • Aim 2: To examine the effects of acute aerobic exercise at 60-70% HRRmax 30-minute bout on changes in GM-released SCFA concentrations in stool and plasmatic metabolome.

Being studied: Aerobic Exercise

Conditions: Weight Management; Obesity; Exercise; Women; Gut Microbiome; Metabolome; Health; Gut Microbiota

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Biological sex: female
  • BMI 19 to 24.99 kg/m2 or BMI 30-40 kg/m2
  • Exercisers: Exercise at least 4 times per week for 60 minutes (a total of 240 minutes per week) on a programmed exercise training either on endurance sports (e.g., running, cycling, triathlon), strength (e.g., powerlifting), or team sports (e.g., rugby, football, soccer)
  • Non-Exercisers: Sedentary individuals who have not reached the PA guidelines (150 minutes of moderate-intensity physical activity a week, 75 minutes of vigorous-intensity physical activity, or an equivalent combination of moderate and vigorous-intensity physical activity).

Exclusion Criteria

  • Biological sex: male
  • BMI \< 19 kg/m2 or > 40 kg/m2
  • Currently pregnant, \< 2 years postpartum, lactating
  • Currently taking any herbal, fiber, or prebiotic supplement
  • Current or 1-month before the study, taking oral or vaginal antibiotics
  • Diagnosed with any gastrointestinal, endocrine, digestive, cancer, or cardiovascular disease.

Recruiting US locations

  • Milken Institute School of Public Health, The George Washington University

    Washington D.C., DC 20037

    Site contact: Carmen Ortega-Santos, PhD, RD · 202-994-2757 · carmen.ortegasantos@gwu.edu

Study contacts (from the official record)

  • Carmen Ortega-Santos, PhD, RD · 2029942757 · carmen.ortegasantos@gwu.edu
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How a Single Workout Affects Gut Bugs in Women With Different… (NCT06691100) | Bored Studies