Skip to content
Bored Studies
RecruitingAccepts healthy volunteers

Hyperpolarized 129-Xenon Imaging in Adult Hematopoietic Cell Transplant Recipients With Pulmonary Impairment

M.D. Anderson Cancer Center · NCT05041140

View Study & Apply (opens in a new tab)

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
25
US sites recruiting
1
Study start
August 14, 2024
Record last updated
August 25, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study is designed to measure the correlation of hyperpolarized 129-Xe magnetic resonance imaging (129-XeMRI) in allogeneic hematopoietic cell transplant (allo-HCT) recipients at MD Anderson Cancer Center (MDACC) who develop bronchiolitis obliterans syndrome (BOS) or BOS stage 0p (pulmonary impairment not meeting the definition for BOS, defined below) and controls with chronic graft-versus-host disease (cGVHD).

The primary objective of the study is to correlate 129-Xenon measures of ventilation, gas exchange, and pulmonary circulation with spirometric and quantitative CT measurements.

A secondary objective is to determine whether measurement of 129-Xe MRI characteristics in patients with BOS stage 0p can predict BOS progression 6 months after enrollment.

Being studied: 29-XeMRI imaging

Conditions: Pulmonary; Pneumonia; Hematopoietic System--Cancer

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Allo-HCT recipients who are at least 18 years of age and have BOS (n=10 patients), BOS 0p (n = 10 patients), or cGVHD of a non-lung organ without evidence of pulmonary impairment (n = 5 patients).

Healthy Cohort - Inclusion Criteria

We will perform only XeMRI imaging on 10 healthy adult (18 years and older) volunteers with no medical issues for technical calibration of the XeMRI technology. Members of the study team may serve as healthy volunteers if they have no prior history of lung disease. These data will not be included as part of the analysis.

Exclusion Criteria

  • Participants unable to follow up at MD Anderson for routine clinical care
  • Inability or unwillingness to give informed consent
  • Relapsed disease or life expectancy less than 6 months at time of enrollment
  • Severe claustrophobia precluding MRI imaging
  • Active pulmonary infection
  • Pregnant women

Recruiting US locations

  • M D Anderson Cancer Center

    Houston, TX 77030

    Site contact: Ajay Sheshadri

Study contacts (from the official record)

  • Ajay Sheshadri · (713) 563-1987 · asheshadri@mdanderson.org
All healthy volunteers studies in Texas →
Hyperpolarized 129-Xenon Imaging in Adult Hematopoietic Cell… (NCT05041140) | Bored Studies