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Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: a Dimensional Approach

The University of Texas Health Science Center, Houston · NCT03705715

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–80 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 1
Target enrollment
200
US sites recruiting
1
Study start
May 1, 2017
Record last updated
March 19, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this research is to determine whether there is more extensive inflammation in the brain of people with clinical evidence of neuropsychiatric syndromes, such as mood disorder, chronic pain syndrome, dementia, traumatic brain injury, or substance abuse. The research will also explore whether there is more inflammation in patients with more neuropsychiatric symptoms. Inflammation in the brain will identified by using Positron Emission Tomography (PET) with the radiotracer [11C]PBR-28 or [11C]ER176.

Being studied: PET with radiotracer [11C]PBR-28 ( or [11C]ER176); Affective challenge

Conditions: Neuropsychiatric Syndromes

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Must be between 18-80 years old
  • Males or females
  • Must be right handed
  • Must be able to sit unaccompanied for long periods of time with little body movement
  • Must be illicit drug free at time of scanning as appropriate (UDS negative),
  • Must be either healthy (without medical, neurological, psychiatric illness) or have a diagnosis of a neuropsychiatric syndrome (mood disorder, chronic pain syndrome, dementias, traumatic brain injury, substance/alcohol use disorder).
  • Healthy Control volunteers must be medication free (≥ 14 days)
  • Illicit drug free at time of scanning (verified by negative urine drug screen)

Exclusion Criteria

  • Must not be a smoker.
  • Females must not be pregnant or nursing.
  • Must not suffer from claustrophobia
  • Must not meet exclusion criteria for MRI scanning (i.e. non-fixed magnetisable objects)
  • Must not be PBR-28 low affinity binder (or using the [11C]ER176 study radiotracer)
  • Healthy control volunteers must not have on-going, chronic, or relapsing/remitting medical, psychiatric (absence of both DSM-IV Axis I and/or Axis II disorders), or neurological illness as determined by combination of history, medical record, and/or examination.

Recruiting US locations

  • BBSB at UTHealth

    Houston, TX 77054

    Site contact: alan R Prossin, MBBS · 713-486-2836 · alan.prossin@uth.tmc.edu

Study contacts (from the official record)

  • Alan Prossin, MBBS · 713-486-2836 · alan.prossin@uth.tmc.edu
All mental health studies in Texas →
Identifying Correlates of Brain Microglial Activation in… (NCT03705715) | Bored Studies