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IH, Brain Health, and T2D

Darren P Casey · with American Diabetes Association · NCT07173543

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 60–85 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
80
US sites recruiting
1
Study start
September 22, 2025
Record last updated
March 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to use a randomized, placebo-controlled study design to rigorously examine the therapeutic potential of intermittent hypoxia (IH) for improving cerebrovascular health in older adults with and without type 2 diabetes mellitus (T2DM).

Being studied: Intermittent Hypoxia 1 (IH1); Intermittent Hypoxia 2 (IH2); SHAM - normoxia

Conditions: Type 2 Diabetes; Aging

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

For 30 patients with documented Type 2 diabetes

Inclusion Criteria

  • Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures.
  • Age is > or = 60 and \< or = 85 years of age
  • Documented Type 2 diabetes
  • Scoring 26 or higher on the MoCA test

Exclusion criteria

  • diagnosis of type 2 diabetes \< 1 year prior to enrollment
  • HbA1c \<6.5% or >10.0%
  • body mass index > 40 kg/m 2
  • incident cardiovascular events in the last year (heart attack, stroke)
  • symptomatic coronary artery disease and/or heart failure
  • uncontrolled hypertension
  • obstructive sleep apnea
  • pulmonary disease
  • dementia
  • renal impairment with creatinine clearance (eGFR) of \<60 ml/min
  • smoking or history of smoking within past one year

30 nondiabetic control subjects will also be studied.

Inclusion criteria

  • Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures.
  • Age is > or = 60 and \< or = 85 years of age
  • Scoring 26 or higher on the MoCA test

Exclusion criteria

  • Diagnosis of diabetes (Type 1 or Type 2)
  • body mass index > 40 kg/m2
  • incident cardiovascular events in the last year (heart attack, stroke)
  • symptomatic coronary artery disease and/or heart failure
  • uncontrolled hypertension
  • obstructive sleep apnea
  • pulmonary disease
  • dementia
  • renal impairment with creatinine clearance (eGFR) of \<60 ml/min
  • smoking or history of smoking within past one year

Recruiting US locations

  • University of Iowa

    Iowa City, IA 52242

    Site contact: Darren P Casey, PhD

Study contacts (from the official record)

  • Darren Casey, PHD · 13193841009 · darren-casey@uiowa.edu
All diabetes studies in Iowa →
IH, Brain Health, and T2D (NCT07173543) | Bored Studies