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Imaging Biomarkers in ALS

University of Minnesota · NCT02567136

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 21–75 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
30
US sites recruiting
1
Study start
September 2015
Record last updated
December 2, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of the study is to determine if we are able to find one or more biomarkers of Amyotrophic Lateral Sclerosis (ALS) and Primary Lateral Sclerosis (PLS) using magnetic resonance imaging (MRI) scans at different levels, 3 tesla (3T) and 7 tesla (7T). A biomarker is a measurable characteristic that can be used as an indicator of a particular disease state. Identifying biomarkers of a disease can lead to a better understanding of the disease as well as improved treatments. This study will enroll patients with ALS, PLS, and healthy controls.

Conditions: Amyotrophic Lateral Sclerosis; Primary Lateral Sclerosis

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 21 to 75 years of age inclusive.
  • Willing and able to give signed informed consent that has been approved by the Institutional Review Board (IRB).

ALS patients

  • A clinical diagnosis of possible, laboratory-supported probable, probable, or definite ALS, according to a modified El Escorial criteria.

Exclusion Criteria

  • Diagnosis of other neurodegenerative diseases (Parkinson disease, Alzheimer disease, etc).
  • Clinically significant history of unstable medical illness (unstable angina, advanced cancer, etc) over the last 30 days.
  • Inability to undergo MRI scanning, including but not limited to unable to remain still in an MRI scanner for more than 30 minutes, claustrophobia, presence of paramagnetic substances or pacemakers in body, weight over 300 lbs, or in the opinion of the investigator, if there is a strong likelihood that the subject would not be able to lie flat comfortably for 75-90 minutes.
  • The subject requires assistance to ambulate OR climb stairs, unless in the opinion of the investigator, and based upon the subject's rate of disease progression, the subject is likely to be able to participate in the MRI screening 12 months after enrollment.

Recruiting US locations

  • University of Minnesota

    Minneapolis, MN 55414

    Site contact: Valerie Ferment · 612-301-1535 · ferm0016@umn.edu

Study contacts (from the official record)

  • Valerie Ferment · 6123011535 · ferm0016@umn.edu
All neurology studies in Minnesota →
Imaging Biomarkers in ALS (NCT02567136) | Bored Studies