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Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the Human Brain

University of Texas Southwestern Medical Center · NCT03849963

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–60 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
28
US sites recruiting
1
Study start
July 30, 2030
Record last updated
March 12, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Investigators propose to develop hyperpolarized [13C]-labeled pyruvate as potential imaging probes to assess two essential in vivo processes in cerebral metabolism: oxidative metabolism and synthesis of a neurotransmitter in this observational study.

Conditions: Brain Metabolism

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 18 through 60 years of age.
  • Healthy, with no neurological abnormalities.
  • Ability to understand and the willingness to sign a written informed consent.
  • All races and ethnicities will be included; subjects must be able to read and speak the English language.

Exclusion Criteria

  • Metallic foreign bodies on the scalp or cranium which may interfere with MRI acquisitions
  • Major debilitating neurological disease including, but not limited to, stroke, CVA, dementia and tumor that would limit compliance with study requirements
  • Under influence of illicit drugs which are known to alter brain physiology/metabolism including, but not limited to cocaine, lysergic acid diethylamide (LSD), and marijuana at the time of MRI/MRSI scanning.
  • Under influence of antiepileptic drugs at the time of MRI/MRSI scanning.
  • Any contraindication per MRI Screening Form including
  • Implants contraindicated at 3T, pacemakers
  • Implantable Cardioverter Defibrillator (ICD)
  • Claustrophobia
  • Medically unstable including
  • Heart failure
  • Severe left ventricular outflow tract (LVOT) obstruction
  • Unstable angina
  • Pregnancy
  • Lactating

Recruiting US locations

  • UT Southwestern - Advanced Imaging Research Center

    Dallas, TX 75390

    Site contact: Jeannie D Baxter, RN · 214-645-2726 · jeannie.baxter@utsouthwestern.edu

All healthy volunteers studies in Texas →
Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the… (NCT03849963) | Bored Studies