Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)
MaineHealth · with National Institute of General Medical Sciences (NIGMS), National Heart, Lung, and Blood Institute (NHLBI) · NCT02664831
Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.
Key facts
- Compensation
- Not posted. Ask the study team before screening.
- Who can join
- Ages 18+ · All sexes
- Healthy volunteers
- Accepted
- Study type
- Observational
- Target enrollment
- 400
- US sites recruiting
- 1
- Study start
- January 2016
- Record last updated
- July 18, 2025
Status re-checked against ClinicalTrials.gov within the last 12 hours.
What the study is about
This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after cardiac arrest. Investigators have shown that cardiac arrest induces changes in the numbers and properties of circulating immune cells, shifting the balance towards a pro-inflammatory phenotype and there is increased interest in the inflammatory pathways and the signaling mechanisms through which they are modulated. Participants will undergo blood sampling during 7 days following cardiac arrest, and analyses performed. Patient characteristics, clinical circumstances, and outcomes will be recorded and their associations with these inflammatory pathways characterized.
Conditions: Cardiac Arrest; Inflammation; Obesity; Hypoxic Ischemic Encephalopathy (HIE)
Eligibility criteria
Copied from the official record. The study team makes the final decision at screening.
Show full criteria
Inclusion Criteria
- Aged 18 years or older
- Admitted to the intensive care unit after cardiac arrest episode
- Unresponsive after resuscitation
Exclusion Criteria
- Moribund / actively dying at the time of evaluation
- Informed consent cannot be obtained within 24 hours of resuscitation
- Hemoglobin less than 7.0 g/dL, active high-volume bleeding, or requiring a transfusion
Recruiting US locations
Maine Medical Center
Portland, ME 04102
Site contact: David B Seder, MD · 207-662-2179 · david.seder@mainehealth.org
Study contacts (from the official record)
- David B Seder, MD · 207-662-2179 · david.seder@mainehealth.org
- Sergey Ryzhov, PhD · sergey.ryzhov@mainehealth.org