Skip to content
Bored Studies
RecruitingAccepts healthy volunteers

Impact of Circulating and Tissue-specific Lipids on Vascular Function and Insulin Sensitivity in Chronic Night Shift Workers

Colorado State University · with University of Colorado, Denver, National Heart, Lung, and Blood Institute (NHLBI) · NCT06550115

View Study & Apply (opens in a new tab)

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–65 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
50
US sites recruiting
1
Study start
March 1, 2024
Record last updated
December 17, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

People who experience repeated bouts of circadian misalignment, such as shift workers, are at higher risk of cardiovascular disease (CVD) and Type 2 diabetes (T2D) compared to daytime workers. However, the mechanism(s) by which shift work and associated circadian misalignment increase CVD and T2D risk are unknown. This project will examine whether elevated plasma lipids are a mechanism by which circadian misalignment impairs vascular function, insulin sensitivity, glucose homeostasis and muscle lipid accumulation, which could be targeted to prevent and treat cardiometabolic disease in people who chronically experience circadian misalignment, which includes more than 20% of the US workforce.

Being studied: Time-restricted eating; Control eating

Conditions: Circadian Rhythm Sleep Disorder of Shift Work Type; Metabolic Disease; Insulin Sensitivity; Blood Pressure

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 18-65 years old
  • worked the night shift for the last 1 year or more,
  • habitually sleep 5-9 hours per 24h period (night shift workers typically experience chronic insufficient sleep),
  • body mass index (BMI) of 20.0 - 35.0 kg/m2 and weight stable (plus or minus 5% of current body weight in the last 6 months); sedentary to mild physical activity level (less than 2 days of planned exercise per week);

Exclusion Criteria

  • existing diagnosed sleep or eating disorder (e.g. obstructive sleep apnea [OSA], periodic limb movements of sleep [PLMS], narcolepsy, travel more than 1 time zone in 3 weeks before the study; anorexia nervosa, more than one food allergy to maintain flexibility in diet planning);
  • following any TRE (time-restricted eating) or intermittent fasting plan in the last year;
  • following any special diet plan, like paleo, keto, gluten-free or vegan, that can affect the primary lipid outcome measures in the last 6 months; any clinically significant surgical condition within the last year;
  • diagnosed diabetes or cardiovascular disease
  • The prevalence of insomnia in shift workers is fairly high, ranging from 12.8% to 76.4%, which is higher than estimated for the general population. Insomnia itself is associated with elevated neural cardiovascular responsiveness to stress compared to people without insomnia. Thus, since excessive sleepiness and symptoms of insomnia may be present in night shift workers they will not be exclusionary.

Recruiting US locations

  • Colorado State University

    Fort Collins, CO 80523

    Site contact: Ellen Lyon, MS · 970-491-3103 · ellen.lyon@colostate.edu

Study contacts (from the official record)

  • Josiane L Broussard, PhD · 9704913103 · josiane.broussard@colostate.edu
  • Ellen Lyon, MS · 9704913103 · ellen.lyon@colostate.edu
All diabetes studies in Colorado →
Impact of Circulating and Tissue-specific Lipids on Vascular… (NCT06550115) | Bored Studies