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Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes

Ball State University · NCT07095426

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–55 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
20
US sites recruiting
1
Study start
May 20, 2025
Record last updated
July 31, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Based on prior research, the investigators are interested in whether an intervention targeting gut health (supplemental fiber for 9 weeks total) will improve vascular health in individuals with obesity. Additionally, the investigators are interested in if this response differs based on whether individuals with obesity have very few heart disease risk factors or several heart disease risk factors.

Being studied: inulin

Conditions: Metabolic Syndrome; Healthy Participants; Metabolically Healthy Obesity; Metabolically Abnormal Obesity

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Participants are 18-55 years old.
  • Participants BMI is ≥30 kg/m2 - this BMI requirement is due to our research aims.
  • Participants have either 0-1 or 2+ of the following risk factors outside of the normal reference ranges: blood pressure, blood sugar, triglycerides, and HDL-cholesterol.
  • Participants are not pregnant or expecting to become pregnant (females only). •Participants are not postmenopausal (females only).
  • Participants have not been diagnosed with an advanced cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes).
  • Participants have not been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease, diverticulosis/diverticulitis).
  • Participants do not regularly take anti-inflammatory drugs (more than 2x week) and are willing to suspend use of these medications for 3 days leading up to in-lab visits.
  • Participants do not take weight-loss medications (e.g., Ozempic, Wegovy).
  • Participants do not use tobacco products or any illicit drugs.
  • Participants have not used antibiotics or probiotics in the last month.
  • Participants do not have dietary restrictions prohibiting them from consuming the fiber supplement (e.g., food allergies/intolerance).
  • Participants do not have a pacemaker.
  • Participants are able to lie on their back (supine position) in the dark for at least 10 minutes (related to vascular measurements).

Exclusion Criteria

  • Participants are not 18-55 years old.
  • Participants BMI is not ≥30 kg/m2 - this BMI requirement is due to our research aims.
  • Participants do not have either 0-1 or 2+ of the following risk factors outside of the normal reference ranges: blood pressure, blood sugar, triglycerides, and HDL-cholesterol.
  • Participants are pregnant or expecting to become pregnant (females only).
  • Participants are postmenopausal (females only).
  • Participants have been diagnosed with an advanced cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes).
  • Participants have been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease, diverticulosis/diverticulitis). •Participants regularly take anti-inflammatory drugs (more than 2x week) and are not willing to suspend use of these medications for 3 days leading up to in-lab visits.
  • Participants take weight-loss medications (e.g., Ozempic, Wegovy).
  • Participants use tobacco products or any illicit drugs.
  • Participants have used antibiotics or probiotics in the last month.
  • Participants have dietary restrictions prohibiting them from consuming the fiber supplement (e.g., food allergies/intolerance).
  • Participants have a pacemaker.

Recruiting US locations

  • Health Professions Building

    Muncie, IN 47306

    Site contact: Bryant Keirns, PhD · 765-285-8356 · bryant.keirns@bsu.edu

Study contacts (from the official record)

  • Bryant Keirns, PhD · 765-285-8356 · bryant.keirns@bsu.edu
All weight loss studies in Indiana →
Impact of Supplemental Fiber on Gut and Vascular Health Related in… (NCT07095426) | Bored Studies