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Improving Medication Adherence Using Family-focused and Literacy-sensitive Strategies

Jia-Rong Wu · with National Institute of Nursing Research (NINR) · NCT05548413

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
328
US sites recruiting
1
Study start
January 4, 2023
Record last updated
May 5, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

People with heart failure who do not take their medications as prescribed are at high risk of complications leading to hospitalization, death and poor quality of life. In the proposed intervention, nurses will use easy-to-understand language to coach patients and their care partners to help them work together and build skills to overcome their individual barriers to adherence in order to 1) improve and sustain patient medication adherence; 2) reduce hospitalization; 3) improve quality of life. If effective, this intervention will support long-term medication adherence, thus reducing hospitalizations related to heart failure and quality of life.

Being studied: FamLit; Attention Control

Conditions: Medication Adherence; Heart Failure

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria - Patient Participants

  • confirmed diagnosis of heart failure (HF), either systolic or diastolic HF
  • ave suboptimal medication adherence
  • have a care partner (CP) (either spouse, daughter/son, partner, other relative, friend) who is identified by the patient as the person most involved in HF care
  • willingness to have a CP be involved in their medication taking
  • have undergone evaluation of HF and prescribed stable doses of HF medications for at least 3 months
  • live in a setting where the patient is responsible for their ow medication administration
  • willing to use the SimpleMed+ (i.e., an electronic pillbox to measure objective medication adherence)
  • availability by phone

Exclusion Criteria - Patient Participants

  • cognitive impairment as indicated by having difficulties to understand and give informed consent
  • a recent hospitalization within 3 months of study enrollment
  • co-existing end-stage renal disease or terminal illness such as advanced malignancy, or any other condition with less than 1-year life expectancy
  • psychotic illness
  • current alcohol dependence or other substance abuse
  • inability to speak English or other communication barrier
  • currently or have received any similar self-care intervention recently in the past year

Inclusion Criteria - Care Partners

  • unpaid family member, friend, partner, or other relation who is involved in the patients' care at least 3 times a week, designated by the patient
  • willing to receive interventions with the patient together
  • 18 years of age or older

Exclusion Criteria - Care Partners

  • cognitive impairment as indicated by having difficulties to understand and give informed consent
  • coexisting terminal illness
  • non-English speaking or any other communication barrier

Recruiting US locations

  • Jia-Rong Wu

    Lexington, KY 40536

    Site contact: Jia-Rong Wu, PhD · 859-323-4712 · jiarong.wu2@uky.edu

Study contacts (from the official record)

  • Jia-Rong Wu, PhD · 8593234712 · jiarong.wu2@uky.edu
All heart & blood pressure studies in Kentucky →
Improving Medication Adherence Using Family-focused and… (NCT05548413) | Bored Studies