Improving Smoking Abstinence Outcomes in the African American Community Through Extended Treatment

Inclusion Criteria

• African American
• age >18 years
• interested in quitting
• smoked >1 cpd for >1 years
• smoked on >25 days in the past month
• willing to take 6 months of study medication and complete all visits
• have a home address and functioning telephone number

Exclusion Criteria

• Consistent with contraindications for bupropion:
• use of psychoactive medications
• history of alcohol or substance abuse within the past year
• binge drinking (>5 drinks on one occasion) >2 times in the past month
• history of seizures or head trauma; history of bulimia or anorexia nervosa
• pregnant (as measured by over the counter pregnancy test kit for women of child-bearing age only) or contemplating pregnancy; breast feeding
• myocardial infarction in the past 2 months
• reported use of opiates, cocaine, or stimulants
• unstable diabetes
• bupropion is a known inhibitor of the liver enzyme CYP2D6, so those taking drugs known to be higher metabolized by this enzyme (e.g., metoprolol, tamoxifen) will be excluded.
• use of stop smoking medications (bupropion, varenicline, nicotine replacement, fluoxetine, clonidine, buspirone, or doxepin) in the past 30 days
• planning to move from the Kansas City area in the next year
• other smoker in household enrolled in the study.