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RecruitingAccepts healthy volunteersPhase 4

Insights in Endocervical Mucus Secretion

Oregon Health and Science University · with National Institutes of Health (NIH), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · NCT07111247

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 21–40 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
15
US sites recruiting
1
Study start
January 2, 2026
Record last updated
January 8, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Single arm interventional study looking at biological outcomes at 4 time points throughout the cycle before and after taking an oral gonadotropin-releasing hormone antagonist (gnRH). Samples of whole blood, endocervical mucus, endocervical biopsy, and vaginal swab will be collected.

Being studied: Gonadotropin Releasing Hormone Antagonists Relugolix

Conditions: Cervical Mucus

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Normal menstrual cycles of 25-35 days in length for at least the previous 3 cycles
  • BMI >18 and \<35
  • Serum p4 >= 3 ng/ml on single sample collected between days 18-25 of self-reported menstrual cycle
  • Flexible schedule allowing blood draws on less than 48 hour notice
  • In good general health
  • Commit to using non-hormonal contraceptive methods without spermicide during study period except those prescribed in the experimental protocol
  • No objections to taking study drugs
  • No objections to refraining from intercourse the night before any sampling and willing to use condoms during vaginal intercourse

Exclusion Criteria

  • Oral contraceptive use or other hormone supplement within the preceding 2 months
  • Current cervical infection
  • Evidence of abnormal cervical cytology
  • Use of any IUD for contraception
  • Long-acting hormonal contraceptive use in the past 12 months (e.g., Depo-Provera)
  • Contraindications to study drugs
  • Current or past pregnancy within the previous 6 months or currently trying to conceive
  • Desiring to conceive in the next 8 months
  • Breastfeeding in the past 2 months
  • Diagnosed diabetes or metabolic syndrome
  • Diagnosed Polycystic Ovary Syndrome
  • History of, or self-reported, substance abuse
  • Smoker
  • Previous infertility treatment excluding male factor issues
  • Use of an investigational drug within the past 2 months
  • History of excisional or ablative treatment procedure on cervix (i.e., LEEP, Cryotherapy, Cold Knife Cone)
  • Current treatment for a vaginal infection such as bacterial vaginosis
  • History of venous thromboembolism (VTE) or inherited thrombophilias

Recruiting US locations

  • Oregon Health & Science University

    Portland, OR 97239

    Site contact: Leo Han, MD

Study contacts (from the official record)

  • Women's Health Research Unit Recruitment Line · 503-494-3666 · whru@ohsu.edu
All healthy volunteers studies in Oregon →
Insights in Endocervical Mucus Secretion (NCT07111247) | Bored Studies