Skip to content
Bored Studies
RecruitingAccepts healthy volunteers

Interactive Effects of Sodium and Potassium on Vascular Health in Older Adults

Florida State University · with University of Florida · NCT07649005

View Study & Apply (opens in a new tab)

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 55–75 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
30
US sites recruiting
1
Study start
March 24, 2026
Record last updated
June 15, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trial is to determine if a high potassium intake can counteract the harmful effects of excess sodium on endothelial function in older adults with no history of cardiometabolic disease. The main questions it aims to answer are:

  • Can a high potassium intake attenuate dietary sodium-induced endothelial dysfunction in older adults.
  • Do changes in endothelial function in response to alterations in sodium and potassium intake differ by sex.

Participants will participants will consume three controlled diets for 10 days each with a minimum 14-day washout between interventions. The order in which participants consume the diets will be randomized. The study diets will vary in sodium and potassium content. Measures of cardiovascular health (blood pressure, arterial stiffness, endothelial function) will be assessed at the end of each diet.

Being studied: low sodium/low potassium diet; high sodium/low potassium diet; high sodium/high potassium diet

Conditions: Healthy Older Adults

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Adults ages 55-75 years
  • At least one-year post-menopause (females)
  • Willing and able to attend laboratory visits

Exclusion Criteria

  • BMI ≥35 kg/m2
  • Seated blood pressure >135/85 mmHg
  • Current diagnosis or history of cardiovascular disease, diabetes, renal disease, cancer, or major cardiovascular event (e.g. heart attack or stroke)
  • Taking exogenous hormones or hormone replacement therapy
  • Following a vegan or gluten free diet
  • Significant weight loss (>10% of body weight) in the last 6 months, or actively trying to lose weight
  • Current or recent use of a diuretic (within the past 6 months) (e.g. spironolactone, eplerenone)
  • Current or recent use of a potassium binding medication (within the past 6 months)
  • Current use of blood pressure lowering medications (e.g. ACE inhibitors, calcium channel blockers, diuretics, vasodilators, beta blockers, AngII receptor blockers)
  • Current or recent use of the medication trimethoprim
  • Elevated blood lipids (LDL cholesterol ≥190 mg/dL)
  • Elevated serum potassium level (>5.1 mmol/L)
  • Elevated BUN (>22 mg/dL)
  • Elevated creatinine (>1.2 mg/dL)
  • Low eGFR (\<90 mL/min/1.73 m²)
  • Current or recent use of tobacco, nicotine, or illicit drugs
  • Radical hysterectomy or oophorectomy (females)

Recruiting US locations

  • Florida State University

    Tallahassee, FL 32306

    Site contact: Andrea Lobene · 850-644-1829 · alobene@fsu.edu

Study contacts (from the official record)

  • Andrea Lobene · 850-644-1829 · alobene@fsu.edu
  • FSU Ann's College · 850-644-6685
All heart & blood pressure studies in Florida →
Interactive Effects of Sodium and Potassium on Vascular Health in… (NCT07649005) | Bored Studies