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Interventions for Postoperative Delirium: Biomarker-3

University of Wisconsin, Madison · with National Institute on Aging (NIA) · NCT03124303

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 60+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
468
US sites recruiting
1
Study start
February 13, 2017
Record last updated
December 15, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The IPOD-B3 study aims to characterize the relationship between premorbid brain activity and postoperative delirium in patients undergoing major surgery. This is a expansion of the NeuroVISION Bolt-On study, NCT01980511.

Being studied: High Density-Electroencephalogram; Magnetic Resonance Imaging; Blood specimen collection; Pupillometry

Conditions: Delirium

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Cohort 1: Age ≥65 years
  • Cohort 2: Age ≥60 years
  • Anticipated length of hospital stay of at least 2 days after surgery that occurs under general or neuraxial anesthesia
  • Written Informed Consent for potential participation prior to surgery

Exclusion Criteria

  • Contraindication to EEG
  • Unable or unwilling to attend the follow-up appointments
  • Documented history of dementia
  • Deemed incapable of providing consent by surgical team
  • Residing in a nursing home
  • Undergoing intracranial surgery
  • Unable to complete neurocognitive testing due to language, vision or hearing impairment
  • Unable to communicate with the research staff due to language barriers
  • For optional MRI portion of the study: Contraindication to MRI (e.g., implanted devices not safe for MRI studies, claustrophobia, unable to lie flat or still)

Recruiting US locations

  • University of Wisconsin-Madison

    Madison, WI 53792

    Site contact: David Kunkel, BS · 608-262-6469 · dkunkel@wisc.edu

Study contacts (from the official record)

  • David Kunkel, BS · 608-262-6469 · dkunkel@wisc.edu
  • Frankie Ingram, BS · 608-262-6469 · fingram@wisc.edu
All healthy volunteers studies in Wisconsin →
Interventions for Postoperative Delirium: Biomarker-3 (NCT03124303) | Bored Studies