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RecruitingAccepts healthy volunteersPhase 3

Intra-operative Loop Diuretics to Improve Same-day Discharge Rates After HoLEP

Northwestern University · NCT05620784

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–89 · Men only
Healthy volunteers
Accepted
Study type
Interventional · Phase 3
Target enrollment
138
US sites recruiting
1
Study start
March 1, 2023
Record last updated
September 13, 2023

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Holmium Laser Enucleation of the Prostate (HoLEP) is a size-independent treatment option for benign prostatic hypertrophy (BPH) as recommended by the American Urological Association (AUA) Guidelines. Loop diuretics (furosemide) have been given historically during the morcellation portion of HoLEP to promote urine production in the post-operative setting and to minimize the impact of fluid absorption during long periods of morcellation. The intra-operative use of 20mg IV furosemide in perioperative HoLEP pathways has been propagated with the dissemination of HoLEP across North America without evidence to support its routine administration. With increasing surgical efficiency from improvements in laser and morcellator technology, the role of intra-operative furosemide is unknown. This study is designed to assess if there is a significant difference in same day discharge rates after Holmium Laser Enucleation of the Prostate (HoLEP) with and without IV furosemide. .

Being studied: Furosemide

Conditions: BPH With Urinary Obstruction; BPH; Hematuria; Same Day Discharge

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Males 18 -89 undergoing HoLEP
  • Willing to sign the Informed Consent Form
  • Able to read, understand, and complete patient questionnaires.

Exclusion Criteria

  • Allergy or hypersensitivity to furosemide or other loop diuretic
  • Anuric patients or patients with liver failure
  • Patients having a concurrent ureteroscopy +/- laser lithotripsy, percutaneous nephrolithotomy, or non-urologic surgery at the time of their HoLEP
  • Anticipated need for perineal urethrostomy at the time of HoLEP
  • Patient not undergoing catheter removal and voiding trial at Northwestern Memorial Hospital

Recruiting US locations

  • Northwestern University

    Chicago, IL 60611

    Site contact: Nicholas Dean, MD · nicholas.dean@nm.org

Study contacts (from the official record)

  • Nicholas S Dean, MD · 7806906285 · nicholas.dean@northwestern.edu
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Intra-operative Loop Diuretics to Improve Same-day Discharge Rates… (NCT05620784) | Bored Studies