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Investigation of Lymph Node Biology in Kidney Cancer

Yale University · NCT07038733

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
33
US sites recruiting
1
Study start
January 30, 2026
Record last updated
June 16, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this pilot study is to investigate the phenotype, anti-tumor effector functions, and TCR repertoire of T cells isolated from patient tumor draining lymph nodes (TDLNs) to understand T cell priming and trafficking patterns in Renal Cell Carcinoma (RCC). Data and biospecimen collected will be used for current and future research projects involving the study of kidney cancer biology and related medical conditions. Investigators will use this valuable resource to ask clinically relevant translational questions that pertain to biomarker discovery/validation, identification of novel therapeutic targets, and to better understand the genetic and biological basis of the various kidney cancers.

Being studied: Peripheral Blood Sample for Immune Analysis; Tumor Sample for Analysis; Adjacent non-malignant kidney for analysis; Draining lymph node(s) for analysis; Regional non-draining lymph node(s) for analysis

Conditions: Renal Cell Carcinoma (RCC)

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

Candidates for inclusion include adult patients with either a known or suspected kidney cancer referred to Yale Genitourinary Oncology providers in the Yale Urology, Medical Oncology and Radiation Oncology or Nephrology Departments. These individuals will be receiving clinical evaluation/medical treatment/surgery/procedures at Yale New Haven Hospital or the Smilow Cancer Hospital.

Participant eligibility will be determined by study investigators and will be offered protocol details. Interested participants will be invited to participate by study investigators. Consent will be obtained by study investigators or other authorized study personnel. Any potential adult participants with known or suspected kidney cancers with a renal mass who are patients of non-study physicians will be invited to participate by study personal only with the approval of their treating physician.

Exclusion Criteria

  • Participants under the age of 18. Children will not be enrolled on the study.
  • Participants known to be pregnant or actively breastfeeding.
  • Iodine allergy hypersensitivity.

Recruiting US locations

  • Yale University

    New Haven, CT 06510

    Site contact: Jialing Zhang · jialing.zhang@yale.edu

Study contacts (from the official record)

  • Stephanie Ladd · 954-895-0576 · stephanie.ladd@yale.edu
Investigation of Lymph Node Biology in Kidney Cancer (NCT07038733) | Bored Studies