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RecruitingAccepts healthy volunteersPhase 2

Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals

Medical College of Wisconsin · NCT05808686

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 65–85 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 2
Target enrollment
60
US sites recruiting
1
Study start
May 2, 2023
Record last updated
September 23, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trial is to see how small blood vessels respond to the stress of high intensity exercise, and if a safe and simple intervention called ischemic conditioning can protect blood vessels from the stress of exercise.

Participants will come in for 3 study visits and get home-based ischemic conditioning. At Study Visit 1, participants will be assessed for their frailty and physical function. Afterwards, they will perform an exercise test. At Study Visit 2, patients will undergo 2 microvascular assessments, perform a high-intensity exercise, then undergo the same 2 microvascular assessments again. Participants will be given a handheld sphygmomanometer and a blood pressure cuff to take home. Depending on which group the participants get randomized into, participants will place the blood pressure cuff around their non-dominant upper arm and inflate to either a low or high pressure for 2 weeks at home. Participants will repeat the same steps in Study Visit 2 for Study Visit 3. In addition, participants will also be assessed for their frailty and physical function.

Being studied: Ischemic Conditioning

Conditions: Aging; Fragility; Endothelial Dysfunction

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Women and men ages 65-85 years of age

Exclusion Criteria

  • Myocardial infarction in last 6 months
  • morbid obesity (BMI >40)
  • heart failure
  • uncontrolled hypertension
  • other condition that precludes high intensity exercise (ex, neurological disorder, acute systemic infection)
  • history of blood clots in the extremities
  • any condition in which compression of the arm or transient ischemia is contraindicated (e.g., wounds in the arm).

Recruiting US locations

  • Froedtert Hospital

    Wauwatosa, WI 53226

    Site contact: Jennifer Nguyen · 414-955-1917 · jnguyen@mcw.edu

Study contacts (from the official record)

  • Jennifer Nguyen · 414-955-1917 · jnguyen@mcw.edu
  • Matt Durand · 4149555619 · mdurand@mcw.edu
All healthy volunteers studies in Wisconsin →
Ischemic Conditioning to Promote Microvascular Resiliency in Frail… (NCT05808686) | Bored Studies