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Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration Repairs

Florida Atlantic University · with Baptist Health South Florida · NCT06910241

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 3
Target enrollment
100
US sites recruiting
1
Study start
September 3, 2025
Record last updated
January 7, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Diphenhydramine, when injected locally, has been shown to achieve a certain level of local anesthesia. It has been documented for use in simple bedside procedures, however there is a gap in knowledge in its comparison to lidocaine. The purpose of the study is to determine if local infiltration of diphenhydramine is noninferior to the use of lidocaine 1% when trying to achieve local anesthesia for simple laceration repair. Patients who present to the emergency department with a simple laceration will be enrolled in the study. Patients will be evaluated for the pain of the injection as well as the pain of the laceration repair procedure post injection.

Being studied: Lidocaine; Diphenhydramine

Conditions: Laceration of Skin

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Lacerations requiring one layer of sutures
  • Lacerations appropriate for repair by emergency physicians

Exclusion Criteria

  • Active bleeding from laceration
  • Complex lacerations requiring multiple layers
  • Lacerations to be repaired by a specialist service
  • Patients with allergies to either diphenhydramine or lidocaine
  • Laceration repairs would benefit from the use of epinephrine as an additive to the local anesthetic

Recruiting US locations

  • Bethesda Hospital East

    Boynton Beach, FL 33435

    Site contact: Scott M Alter, MD · 561-733-5933 · alters@health.fau.edu

All healthy volunteers studies in Florida →
Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for… (NCT06910241) | Bored Studies