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Lipoprotein Kinetics in T1D

University of Missouri-Columbia · with University of Washington · NCT05179954

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–45 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
30
US sites recruiting
1
Study start
May 9, 2022
Record last updated
February 10, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this research study is to understand how type 1 diabetes (T1D) increases the risk for cardiovascular diseases (heart attack and stroke). To this end, the investigators will compare apolipoprotein and triglyceride kinetics in people wtih T1D and healthy control participants.

Being studied: Metabolic testing

Conditions: Type 1 Diabetes

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age: ≥18 but ≤45 years
  • premenopausal/eumenorrheic and not pregnant or breastfeeding
  • non-obese (body mass index ≥18.5\<30.0 kg/m2)
  • Fasting plasma triglyceride \<150 mg/dL

Additional inclusion criteria for control subjects:

  • Fasting plasma glucose \<100 mg/dL
  • Plasma glucose 2 h after a 75 g oral glucose challenge \<140 mg/dL
  • HbA1c \<5.6%.

Additional inclusion criteria for subjects with T1DM:

  • stable insulin regimen (multiple daily insulin injections or continuous subcutaneous insulin) for at least 8 weeks before screening
  • no use of diabetes medications other than insulin
  • HbA1c \<8.0%, basal (overnight fasted)
  • no severe symptomatic hypoglycemic event associated with a seizure or requiring help from other people or a medical facility in the 6 months prior to screening or metabolic testing

Exclusion Criteria

  • more than 1.5 h of structured exercise/week
  • use of tobacco products, excessive amounts of alcohol, or dietary supplements and/or medications known to affect lipid metabolism
  • hypothyroidism or other disorders known to affect lipid metabolism
  • conditions that would make it impossible to complete the study protocol

Recruiting US locations

  • University of Missouri School of Medicine

    Columbia, MO 65212

    Site contact: Bettina Mittendorfer, PhD · b.mittendorfer@missouri.edu

Study contacts (from the official record)

  • Amanda Heider · (573) 884-6852 · ahmc4@health.missouri.edu
  • Mittendorfer Lab · MittendorferLab@umsystem.edu
All diabetes studies in Missouri →
Lipoprotein Kinetics in T1D (NCT05179954) | Bored Studies