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RecruitingAccepts healthy volunteersEarly Phase 1

Localizing Epileptic Networks Using MRI and iEEG

University of Pennsylvania · with Medical University of South Carolina · NCT04649008

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
290
US sites recruiting
1
Study start
March 1, 2021
Record last updated
February 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Findings from the present study may inform current and new therapies to map and alter seizure spread, and pave the way for less invasive, better- targeted, patient-specific interventions with improved surgical outcomes. This research is relevant to public health because over 20 million people worldwide suffer from focal drug-resistant epilepsy and are potential candidates for cure with epilepsy surgical interventions.

Being studied: 3T Magnetic Resonance Imaging; Intracranial electroencephalography recordings; 7T Magnetic Resonance Imaging

Conditions: Epilepsy; Epilepsy Intractable; Epilepsy, Temporal Lobe

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Patients with medication-refractory epilepsy
  • Planned intracranial EEG (IEEG) placement
  • Hypothesized to have temporal lobe epilepsy

Exclusion Criteria

  • Contraindication to 3T MRI (e.g. metal implants or claustrophobia), clinical features that typically preclude the use of IEEG (e.g. pregnancy), prior intracranial surgery or device, and IEEG findings that are non-diagnostic (e.g. seizure onset zone(s) not identified)

Recruiting US locations

  • University of Pennsylvania

    Philadelphia, PA 19104

    Site contact: Carolyn Wilkinson, BSN · 215-746-4850 · wilkinsc@seas.upenn.edu

Study contacts (from the official record)

  • Kathryn A Davis, MD, MSTR · 215-349-5166 · katedavis@pennmedicine.upenn.edu
All neurology studies in Pennsylvania →
Localizing Epileptic Networks Using MRI and iEEG (NCT04649008) | Bored Studies