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Longitudinal Oral Microbiome Sampling for BE

Columbia University · with University of Michigan, National Cancer Institute (NCI) · NCT05133102

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
275
US sites recruiting
2
Study start
March 19, 2021
Record last updated
May 12, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This is a longitudinal cohort study to assess the impact of repeated sampling of an oral microbiome signature for Barrett's esophagus (BE). Potential participants will be identified through chart review of patients who have had an endoscopy in the past three years.

Being studied: Sample collection

Conditions: Barrett Esophagus

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Scheduled for an upper endoscopy or had upper endoscopy within past three years
  • Eighteen years of age or older
  • Capable of producing a saliva sample
  • Able to give informed consent
  • For BE patients only: Endoscopic evidence of Barrett's esophagus (at least 1 cm maximal BE length; i.e. Prague classification: any C, M≥1), and intestinal metaplasia present on esophageal biopsies

Exclusion Criteria

  • History of head and neck cancer or esophageal squamous cell or gastric cancer
  • History of esophageal or gastric surgery
  • Scheduled to undergo colonoscopy on the day of initial saliva collection
  • Scheduled only for Endoscopic retrograde cholangiopancreatography (ERCP) or Endoscopy ultrasound (EUS) without accompanying standard upper endoscopy on the day of initial saliva collection
  • For BE patients only: History of prior endoscopic therapy for BE except a history of prior Endoscopic mucosal resection (EMR) of focal lesions without subsequent ablative therapy is permitted

Recruiting US locations

  • University of Michigan

    Ann Arbor, MI 48109

    Site contact: Joel H. Rubenstein, MD · jhr@med.umich.edu

  • Columbia University Irving Medical Center

    New York, NY 10032

    Site contact: Julian Abrams, MD · 212-305-1909 · ja660@cumc.columbia.edu

Study contacts (from the official record)

  • Julian Abrams, MD · 212-305-1909 · ja660@cumc.columbia.edu
  • Katharine Boyce, RN · kb3217@cumc.columbia.edu
All healthy volunteers studies in Michigan →
Longitudinal Oral Microbiome Sampling for BE (NCT05133102) | Bored Studies