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Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs

University of Florida · NCT01851642

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
220
US sites recruiting
1
Study start
August 9, 2007
Record last updated
November 6, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to look at how Alpha-1-antitrypsin (AAT) deficiency and Cystic Fibrosis (CF) affect white blood cells in the lungs, called macrophages, and their ability to work.

Being studied: History and physical exam.; Blood draw.; Pulmonary function testing.; Albuterol inhaler.

Conditions: Alpha-1 Antitrypsin Deficiency; AAT Deficiency; AATD; Cystic Fibrosis (CF)

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Signed informed consent
  • Male or female 18 years of age or older
  • Negative pregnancy test for women of childbearing potential
  • Hemoglobin >12.5 g/dl measured on the day of participation
  • Negative urine nicotine test

Exclusion Criteria

  • Pregnancy or breastfeeding
  • Weight \< 50 kg
  • History of anemia requiring blood transfusions, erythropoietin supplementation, or iron supplementation within the past 36 months
  • Known hemoglobin \<12.5 g/dl within the past 90 days
  • Systolic blood pressure > 180 mmHg and/or diastolic blood pressure >100 mmHg
  • Poor venous access
  • Large volume blood donation (>200 ml or 7 ounces) within the previous 56 days (e.g. blood donation for the purposes of blood banking)
  • Clinically significant cardiac, hemostatic or neurological impairment or any other significant medical condition that, in the opinion of the investigator would affect subject safety (e.g., recent myocardial infarction, history of prolonged bleeding time, cerebral vascular accident, advanced cancer or uncontrolled medical condition)
  • Psychiatric or cognitive disturbance or illness that would affect subject safety
  • Current smoker

Recruiting US locations

  • Shands at the University of Florida

    Gainesville, FL 32610

    Site contact: Allison Faunce, B.A. · 352-273-8666 · Allison.Faunce@medicine.ufl.edu

Study contacts (from the official record)

  • Allison E. Faunce, B.A. · 352-273-8666 · Allison.Faunce@medicine.ufl.edu
  • Michelle Owens, RN, BSN · 352-273-6339 · Sandra.Owens@medicine.ufl.edu
All healthy volunteers studies in Florida →
Lung Disease and Its Affect on the Work of White Blood Cells in… (NCT01851642) | Bored Studies