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Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke

Northwestern University · with Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · NCT06598150

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
32
US sites recruiting
1
Study start
May 20, 2023
Record last updated
October 1, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study uses functional magnetic resonance imaging to map neural activity throughout the central nervous system during a shoulder abduction task to characterize what motor pathways are being used post-stroke.

Being studied: Shoulder Abduction

Conditions: Stroke; Hemiparesis

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Adults aged at least 18y
  • Able to perform shoulder abduction task (confirmed during screening and initial examination)
  • Safe to undergo MRI
  • Able to follow visual instructions using MRI-compatible vision correction goggles
  • No brainstem or cerebellar lesions
  • No severe concurrent medical problems
  • Cognitive/attentional capacity to focus on a task
  • Able to communicate in English or Spanish

Additional inclusion criteria for stroke participants:

  • Have sustained only one unilateral subcortical, ischemic lesion in the territory supplied by the Middle Cerebral Artery (confirmed by clinical or radiological reports) at least one year prior to participation in this project
  • Paresis confined to one side, with moderate-to-severe motor impairment of the upper limb (Upper Extremity Fugl-Meyer score between 10 and 45).

Exclusion Criteria

  • MRI contraindications
  • Severe claustrophobia
  • Pregnant women
  • Prisoners
  • Vulnerable populations
  • Diagnosis/history of:
  • multiple sclerosis
  • brain tumor
  • brain radiation
  • traumatic brain injury
  • dementia
  • Parkinson's disease
  • Concurrent enrollment in an intervention study
  • Concurrent use of medications known to suppress central nervous system activity

Recruiting US locations

  • Northwestern University

    Chicago, IL 60611

    Site contact: Michelle Medina, BS · 872-272-7687 · anvil@northwestern.edu

Study contacts (from the official record)

  • Michelle Medina, BS · 872-272-7687 · anvil@northwestern.edu
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Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic… (NCT06598150) | Bored Studies