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Mechanism of Ketogenic Diet-Induced Hypercholesterolemia

Washington University School of Medicine · NCT06894004

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–39 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
100
US sites recruiting
1
Study start
February 24, 2025
Record last updated
March 23, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Very-low carbohydrate ketogenic diets can dramatically increase blood cholesterol levels, particularly in normal-weight people, for reasons that are not well understood. This study will enroll normal-weight adults, will identify "responders" who develop high cholesterol on a ketogenic diet, and will measure rates of production and removal of certain types of cholesterol-carrying particles called lipoproteins in responders. The results will clarify the mechanism by which a ketogenic diet can cause high cholesterol in certain susceptible people.

Being studied: Ketogenic Diet; Control Diet

Conditions: Hypercholesterolemia and Hyperlipidemia

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • age ≥ 18 and \< 40 years
  • BMI ≥ 18.5 and \< 25.0 kg/m2
  • baseline serum LDL-c \< 150 mg/dL (\< 3.9 mmol/L)
  • baseline serum TG \< 100 mg/dL (\< 1.1 mmol/L)
  • HbA1c ≤ 5.6%.

Exclusion Criteria

  • personal or family history of familial hypercholesterolemia
  • current use of lipid-lowering drugs
  • currently on a ketogenic diet and unwilling to change diet
  • current tobacco use
  • hypertension
  • prediabetes or diabetes
  • elevated Lp(a) > 6.5% of ApoB-containing lipoproteins at baseline
  • oral contraceptive use
  • contraindication to heparin
  • known atherosclerotic cardiovascular disease
  • unwilling to abstain from alcohol

Recruiting US locations

  • Washington University School of Medicine

    St Louis, MO 63110

    Site contact: Nikki Plassmeyer, M.A., R.D.N., L.D. · (314) 362-0590 · nikkip@wustl.edu

Study contacts (from the official record)

  • Frannie Wilkinson, M.A. · (314) 362-0590 · francesw@wustl.edu
  • Max C Petersen, M.D., Ph.D. · 314-362-8352 · max.p@wustl.edu
All heart & blood pressure studies in Missouri →
Mechanism of Ketogenic Diet-Induced Hypercholesterolemia (NCT06894004) | Bored Studies