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Mechanisms of Uterine Fluid Absorption During Early Pregnancy ( ELF Study)

Johns Hopkins University · with Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH) · NCT06847685

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–45 · Women only
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
140
US sites recruiting
1
Study start
February 1, 2025
Record last updated
March 9, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The researchers are evaluating mechanisms of uterine fluid absorption during early pregnancy

Conditions: Endometriosis; Endometrioma

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Subject must be a healthy woman between the ages of 18 and 45 years.
  • Women with diagnosed endometriosis or infertility (cases).
  • Women without a diagnosis of endometriosis or infertility (controls).
  • Subject must have regular menstrual cycles.
  • Subject must have a body mass index (BMI) between 18 and 40.
  • Subject must be or have been sexually active or have had a previous vaginal exam that used a speculum.
  • Subject must be able to understand and provide consent to procedures and use/disclosure of protected health information.
  • No history of Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, hepatitis B, and HIV.
  • For IVF study subjects, a minimum endometrial thickness of 7mm at the time of sample collection.

Exclusion Criteria

  • Pregnant women.
  • Study subjects with endometrial cancer.
  • Study subjects with a history of endometrial ablation.
  • Study subjects with undiagnosed uterine bleeding.
  • Women with reproductive diseases that affect the endometrium (such as fibroids or uterine polyps that distort endometrial cavity).
  • Study subjects with an intrauterine device (IUD).

Recruiting US locations

  • Johns Hopkins Hospital

    Baltimore, MD 21287

    Site contact: Samya El Sayed, MD · selsaye4@jh.edu

Study contacts (from the official record)

  • James Segars, MD · 410-614-2000 · jsegars2@jhmi.edu
  • Bhuchitra Singh, MD, MPH, MS, MBA · 410-614-2000 · bsingh10@jhmi.edu
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Mechanisms of Uterine Fluid Absorption During Early Pregnancy (… (NCT06847685) | Bored Studies