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Membrane Potential Mapping with18F-TPP

Yale University · with National Institute for Biomedical Imaging and Bioengineering (NIBIB) · NCT07506616

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 21–80 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 1
Target enrollment
24
US sites recruiting
1
Study start
October 2026
Record last updated
October 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

In this study, investigators propose to use PET imaging to study the pharmacokinetics of 18F-TPP and develop methods for imaging membrane potential (ΔΨT) in humans.

Being studied: 18F-TPP

Conditions: Membrane Potential Mapping

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Willing and able to give voluntary written informed consent
  • Stated willingness to comply with all study procedures and availability for the duration of the study
  • In good general health as evidenced by medical history, physical examination, ECG, serum/urine biochemistry and hematology tests.
  • If female of childbearing potential, must agree to use an acceptable method of birth control, as determined by the principal investigator, for the duration of the study.

Exclusion Criteria

  • Know structural heart disease (e.g. myocardial infarction)
  • Abnormal and clinically significant ECG (as determined by the Investigator or his/her designee) at screening.
  • Laboratory tests with clinically significant abnormalities at screening
  • Pregnancy or Lactation
  • MRI incompatible implants (i.e., such as pacemaker, artificial joints, non-removable body piercings) and other contraindications for MRI, such as claustrophobia, having implanted or embedded metal objects/fragments or fragments in the head or body that would present a risk during the MRI scanning procedure, or have worked with ferrous metals either as a vocation or hobby (for example, as a sheet metal worker, welder, or machinist).
  • Participation in other research studies involving ionizing radiation within one year of the PET scans that would cause the subject to exceed the yearly dose limits followed by the Yale University PET Center.
  • Subject who has current, past, or anticipated exposure to radiation in the workplace within one year of the proposed research scans that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits.
  • Has any condition that, in the opinion of the investigator, would prevent compliance with the study protocol.
  • Arterial Line Exclusion: Blood donation within eight weeks of the start of the study.
  • Arterial Line Exclusion: History of a bleeding disorder or are currently taking anticoagulants (such as Coumadin, Heparin, Pradaxa, Xarelto).
  • Arterial Line Exclusion: Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) greater than 5msec above the upper limit of normal.
  • Arterial Line Exclusion: Unable to safely discontinue or hold aspirin and other NSAID use

Recruiting US locations

Study contacts (from the official record)

  • Shannan Henry · (203) 737-5278 · shannan.henry@yale.edu
  • Kristen Torres, BS · 203-785-4799 · kristen.torres@yale.edu
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Membrane Potential Mapping with18F-TPP (NCT07506616) | Bored Studies