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RecruitingAccepts healthy volunteersPhase 4

Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study

The Cleveland Clinic · NCT07222072

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–72 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
120
US sites recruiting
1
Study start
November 15, 2025
Record last updated
December 17, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and safety of postoperative oral methadone in patients undergoing spine surgery and collect preliminary data to inform a larger clinical trial that will test the opioid-sparing effects of methadone at 3 months after spine surgery.

Being studied: Methadone; Placebo

Conditions: Post Operative Pain; Spinal Surgery

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Adult ≥ 18 years of age
  • Scheduled for multilevel lumbar and/or thoracic spine fusion (primary or revision)

Exclusion Criteria

  • \<18 or >72 Years of age
  • Body Mass Index >40
  • Known allergy to methadone
  • Pregnant females
  • Non-English-speaking patients

Recruiting US locations

  • Cleveland Clinic

    Cleveland, OH 44195

    Site contact: Stephanie Stoianoff, MBA · 216-444-0231 · stoians@ccf.org

Study contacts (from the official record)

  • Stephanie Stoianoff, MBA · 12164440231 · stoians@ccf.org
  • Sandra Durbin, CLPN, CCRP · 216-269-4073 · durbins@ccf.org
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Methadone to Reduce Chronic Opioid Use After Major Spine Surgery:… (NCT07222072) | Bored Studies