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MicroRNA Regulation of Chronic Inflammation During Aging

University of Utah · NCT05392582

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
40
US sites recruiting
1
Study start
November 12, 2024
Record last updated
December 5, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This is an observational study enrolling healthy individuals aged 18-35 and 65y and older to determine the health of immune cells in the blood and how these cells create inflammation and effect health as we age. It is hoped that once the nature of this relationship has been discovered we can more effectively design therapies to reduce this inflammation.

The enrollment goal is 40 participants. The study will occur over the course of 1 month which will include a screening visit and a second visit where the participants will undergo an oral glucose tolerance test, blood draws and leg strength \& exercise tests.

Conditions: Chronic Inflammation

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age between 18 - 35y; 65y and older
  • BMI: \<30 kg/m2
  • Ability to sign informed consent
  • For older participant group: Clinical Frailty Scale score \< 3 and Mini-Cog score > 3
  • Good general medical health, ambulatory and in independent living setting

Exclusion Criteria

  • History of cardiovascular disease (e.g., CHF, CAD, MI, CVA)
  • History of endocrine or metabolic disease such as hypo/hyperthyroidism and diabetes (Treated hypo/hyperthyroid for at least 6 months will be permitted)
  • History of kidney disease or failure (CKD > stage 4)
  • History of vascular disease
  • Uncontrolled hypertension - Elevated systolic pressure >150 or a diastolic blood pressure > 100
  • Cancer or history of successfully treated cancer (less than 1 year) other than basal cell carcinoma
  • Chronic systemic corticosteroid use (≥ 2 weeks) within 4 weeks of enrollment and for study duration (intra-articular/topical/inhaled therapeutic or physiologic doses of corticosteroids will be permitted)
  • Chronic anti-inflammatory medication use (≥ 2 weeks) within 4 weeks of enrollment
  • Chronic inflammatory conditions (e.g., Rheumatoid Arthritis, Crohn's, fibromyalgia, lupus, colitis) HIV, Hepatitis B and C
  • History of stroke with motor disability
  • A recent history (\<12 months) of GI bleed
  • History of liver disease or AST/ALT 2 times above the normal limit
  • History of respiratory disease (acute upper respiratory infection, history of chronic lung disease)
  • Current smokers or current tobacco use
  • Current pregnancy as determined by positive pregnancy test
  • Any staff members who report directly to the principal investigators.

Recruiting US locations

  • The University of Utah

    Salt Lake City, UT 84112

    Site contact: Micah Drummond, PhD · 801-213-2737

Study contacts (from the official record)

  • Micah Drummond, PhD · 801-213-2737 · micah.drummond@hsc.utah.edu
All healthy volunteers studies in Utah →
MicroRNA Regulation of Chronic Inflammation During Aging (NCT05392582) | Bored Studies