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Migraine in Adolescents

Washington University School of Medicine · with National Institute of Neurological Disorders and Stroke (NINDS) · NCT05654012

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 10–13 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
250
US sites recruiting
1
Study start
June 1, 2023
Record last updated
July 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Aim 1. To identify psychophysical and neural factors predicting migraine onset in adolescents

Aim 2a. To determine hormonal, psychophysical, and neural changes associated with migraine onset.

Aim 2b. To identify the temporal relationships between hormonal, psychophysical, and neural changes preceding vs. following migraine onset.

Aim 3. To identify psychophysical and neural factors predicting migraine prognosis in adolescents with migraine.

Being studied: MRI; Thermal Stimuli; Pressure stimuli; Pain ratings; Pressure pain thresholds (PPT); Conditioned pain modulation (CPM) efficiency; Hormonal assessment; Migraine-related measures; Neural assessments; Pubertal status

Conditions: Migraine

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion criteria for healthy participants:

  • Age 10-13
  • Males or females (biological sex)
  • Not diagnosed with migraine or having migraine symptoms
  • With a first degree relative diagnosed with migraine (for the Fam-His group) or without a first or a second degree relative diagnosed with migraine (for the No-Fam-His group)

Inclusion criteria for participants with migraine:

  • Age 10-13
  • Males or females (biological sex)
  • Diagnosed with migraine or having migraine symptoms
  • Migraine duration > 6 months
  • Without preventative treatment or with stable preventative treatment for migraine (no change in intervention in the last 6 months)

Exclusion Criteria for the healthy group

  • Participants will not be enrolled if any of the following criteria exist and based on the investigator discretion:
  • Diagnosis of any chronic pain syndrome
  • Diagnosis of a neurological, developmental, pubertal, or psychiatric disorder
  • Taking pain or psychiatric medications regularly
  • Having an MRI contraindication such as metal in the body or claustrophobia
  • Not able to understand and communicate in English

Exclusion Criteria for the migraine group

  • Participants will not be enrolled if any of the following criteria exist and based on the investigator discretion:
  • Diagnosis of any chronic pain syndrome other than migraine
  • Diagnosis of a neurological, developmental, pubertal, or psychiatric disorder
  • Having an MRI contraindication such as metal in the body or claustrophobia
  • Not able to understand and communicate in English

Recruiting US locations

  • Washington University School of Medicine

    St Louis, MO 63110

    Site contact: Hadas Nahman-Averbuch, PhD · 314-273-6194 · painlab@wustl.edu

Study contacts (from the official record)

  • Alana McMichael, MA · 314-273-6194 · painlab@wustl.edu
  • Hadas Nahman-Averbuch · 314-273-6194
All neurology studies in Missouri →
Migraine in Adolescents (NCT05654012) | Bored Studies