Skip to content
Bored Studies
RecruitingAccepts healthy volunteers

Mitigating Neural Hypoexcitability and Weakness During Disuse in Women

Kansas State University · with National Institute of General Medical Sciences (NIGMS) · NCT07166198

View Study & Apply (opens in a new tab)

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 40–65 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
20
US sites recruiting
1
Study start
May 1, 2026
Record last updated
June 10, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Clinical trial The goal of this clinical trial is to learn how muscle weakness and atrophy develop during short periods of arm immobilization and whether a type of exercise called cross-education can help reduce these effects in women at midlife.

The main questions it aims to answer are

What changes happen in the nervous system that lead to weakness when a wrist is immobilized?

Can training the opposite arm help maintain muscle strength, muscle size, and nervous system function in the immobilized arm?

Researchers will compare women who have their wrist immobilized with or without opposite-arm resistance training.

Participants will

Wear a wrist cast on one arm for 7 days

Complete strength training with the opposite arm or no training, depending on their group

Attend study visits for strength and nervous system testing

Have non-invasive tests (like magnetic brain stimulation, muscle recordings, and muscle imaging) to measure how the nervous system and muscle responds

Being studied: Wrist immobilization; Resistance training; Resistance training rehabilitation

Conditions: Muscle Weakness

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Women between 40-65 years of age
  • Baseline handgrip strength >16Kg

Exclusion Criteria

  • Personal or family history of blood clots
  • Current use of anticoagulant medications
  • Neuromuscular or metabolic diseases (e.g., multiple sclerosis, diabetes)
  • Arthritis
  • Osteoporosis or osteopenia
  • History of myocardial infarction within the past year
  • Chronic pain ≥3/10 for ≥3 months
  • Uncontrolled hypertension (≥140/90 mmHg)
  • Upper extremity surgery within the past year
  • Use of assistive hand or arm device within the past year
  • Fall involving the upper extremities within the past year
  • Upper extremity injuries preventing safe participation
  • Current use of muscle relaxants, benzodiazepines, or similar drugs
  • Smoking within the past 6 months
  • History of drug or alcohol abuse within the past year
  • Severe anxiety or claustrophobia
  • Pregnancy (current or planned)
  • Allergies to medical adhesives
  • High risk of sarcopenia (per SARC-F)
  • Contraindications to TMS or MRI
  • Upper-body resistance training within the past 6 months
  • Inability/unwillingness to refrain from resistance training during study

Recruiting US locations

  • Neuromuscular Physiology Laboratory

    Manhattan, KS 66506

    Site contact: Joshua Carr, PhD · 785-532-0700 · joshuacarr@ksu.edu

Study contacts (from the official record)

  • Joshua Carr, Ph.D. · 785-532-0700 · joshuacarr@ksu.edu
  • Julio Hernandez-Pavon, Ph.D. · juliohpavon@ksu.edu
All healthy volunteers studies in Kansas →
Mitigating Neural Hypoexcitability and Weakness During Disuse in Women (NCT07166198) | Bored Studies