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Molecular Indicators of Systematic Fitness

VO Health, Inc. · NCT07393841

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
250
US sites recruiting
1
Study start
January 5, 2026
Record last updated
February 6, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this study is to characterize associations between cardiorespiratory fitness, as measured by VO₂max/VO₂peak, and blood-based molecular measurements in adults. This is an observational study where research staff measures VO₂max/VO₂peak and collects fasted, resting blood samples on the same day. The main questions it aims to answer are:

  • Can a multi-analyte blood panel accurately predict directly measured VO₂max/VO₂peak?
  • How do these blood-based features vary across age, sex, and self-reported or documented physical activity profiles?
  • Are the predictor analytes able to capture changes in VO₂max/VO₂peak caused by a self-directed intervention (e.g., training for a marathon)?
  • What is the analytic reliability of the predictor biomarkers?

Being studied: There is no intervention.

Conditions: Healthy Adult; Fitness Testing; Athlete; Aging; Exercise Physiology; Human Performance

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Be ≥18 years old
  • Be able to understand and provide informed consent (English; additional languages may be added via amendment with translated materials)
  • Be willing to complete VO₂max testing, blood draw, and questionnaires.
  • Be able to safely perform maximal/symptom-limited exercise testing as determined by: PAR-Q+ screening and investigator review (included as an attachment) and resting vitals screening (heart rate)

Exclusion Criteria

  • Conditions that, in the investigator's judgment, or a medical doctor, makes maximal exercise testing unsafe (e.g., unstable cardiovascular symptoms)
  • Contraindications or unwillingness to undergo venipuncture
  • Acute illness (fever, significant respiratory illness) at the time of testing
  • Failure to comply with procedures.

Recruiting US locations

  • VO Health, Inc.

    New Haven, CT 06510

    Site contact: Brooks P Leitner, MD, PhD · 443-474-7206 · brooks@vohealth.co

Study contacts (from the official record)

  • Brooks P Leitner, MD, PhD · 443-474-7206 · brooks@vohealth.co
  • Sean P Langan, PhD · sean@vohealth.co
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Molecular Indicators of Systematic Fitness (NCT07393841) | Bored Studies