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MRS Measurement of Glutamate and GABA Metabolism in Brain

National Institute of Mental Health (NIMH) · NCT00109174

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–65 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
200
US sites recruiting
1
Study start
September 6, 2006
Record last updated
October 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of [13]C as it is naturally metabolized from glucose to specific chemical transmitters. From this method, we can measure the rate of production of an important excitatory neurotransmitter (glutamate) as well as an inhibitory neurotransmitter (GABA).

Being studied: 3T and 7T device

Conditions: Normal Physiology

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria
  • INCLUSION CRITERIA:
  • 18-65 years of age
  • Able to give written informed consent
  • Healthy based on medical history and physical exam
  • Enrolled in Protocol 01-M-0254 or Protocol 17-M-0181

EXCLUSION CRITERIA

  • Any current Axis 1 diagnosis
  • Clinically significant laboratory abnormalities
  • Positive HIV test
  • Metallic foreign bodies that would be affected by the magnetic resonance imaging (MRI) magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.
  • History of neurological illness or injury with the potential to affect study data interpretation, such as multiple sclerosis, Parkinson s disease, seizure disorder or traumatic brain injury
  • Prescription psychotropic medication, drug free less than 8 weeks (anticholinergics, benzodiazepine, fluoxetine, antipsychotics, and anticonvulsants)
  • Serious medical illness as determined from H\&P or laboratory testing including Diabetes
  • Inability to lie flat on camera bed for about two and a half hours
  • Pregnant or breastfeeding
  • Current substance use disorder based on DSM-5
  • NIMH employees and staff and their immediate family members will be excluded from the study per NIMH policy.

Recruiting US locations

  • National Institutes of Health Clinical Center

    Bethesda, MD 20892

Study contacts (from the official record)

  • Christopher S Johnson · (301) 402-6695 · johnsonchri@mail.nih.gov
  • Li An, Ph.D. · (301) 896-2882 · anl@mail.nih.gov
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MRS Measurement of Glutamate and GABA Metabolism in Brain (NCT00109174) | Bored Studies