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Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX)

Florida Institute for Human and Machine Cognition · with University of Florida, Oklahoma Medical Research Foundation · NCT06507189

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 60+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
250
US sites recruiting
2
Study start
January 27, 2025
Record last updated
August 10, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments that compromise healthspan and quality of life. Exercise is a multipotent treatment with promise to mitigate most aging hallmarks, but there is substantial variability in exercisƒe responsiveness. Combining endurance and resistance training in alignment with public health guidelines will be used to better understand variable exercise responsiveness in older adults with the ultimate goal of improving each older adult's capacity to attain the many health benefits of exercise.

Being studied: Combined endurance and resistance training

Conditions: Aging; Aging Well

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Male or female aged 60 or above
  • Free of chronic disease
  • No structured exercise program (2 or more bouts/wk) within previous 12 months
  • Cognitively capable of providing informed consent

Exclusion Criteria

  • Neuromuscular or musculoskeletal disorder that would limit ability to perform the exercise and/or testing bouts
  • Cardiopulmonary disorders or reduced breathing capacity
  • Metabolic diseases including markers of liver disease (ALT > 52 U/l) and type 2 diabetes (HbA1C = or > 6.5, fasting blood glucose = or > 126 mg/dl)
  • Any other disease or disorder that would influence exercise response (e.g., chronic kidney disease, dementia, current cancer diagnosis or within 2 yr remission, cerebrovascular disease)
  • Any current infectious disease
  • Life expectancy \< 1 year
  • Insulin sensitizing/blood glucose lowering agents such as metformin or metabolic weight loss agents (e.g. GLP-1 agonists)
  • High dose statin (dose equivalent of 40 mg/d or higher simvastatin)
  • Lidocaine allergy
  • Regular tobacco use and/or vaping
  • Excessive alcohol consumption (3 drinks/d or 7 drinks/wk for females; 4 drinks/d or 14 drinks/wk for males)
  • BMI 35.0 kg/m2 or higher
  • Unable to commit to \~6 months required to complete the study

Recruiting US locations

  • Florida Institute for Human and Machine Cognition

    Pensacola, FL 32502

    Site contact: Craig Tuggle · 205-352-6036 · ctuggle@ihmc.org

  • Oklahoma Medical Research Foundation

    Oklahoma City, OK 73104

    Site contact: Ben Miller, PHD · 405-271-7767 · Benjamin-Miller@omrf.org

Study contacts (from the official record)

  • Craig Tuggle · 205-352-6036 · ctuggle@ihmc.org
  • Marcas Bamman, PHD · mbamman@ihmc.org
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